SB-612,111

Из Википедије, слободне енциклопедије
SB-612,111
SB-612,111 structure.png
IUPAC ime
(5S,7S)-7[4-(2,6-dihlorofenil)piperidin-1-il]metil1-metil-6,7,8,9-tetrahidro-5H-benzo[7]anulen-5-ol
Identifikatori
PubChem CID 10047612
IUPHAR/BPS 1693
Sinonimi SB-612,111
Hemijski podaci
Formula C24H29Cl2NO
Molarna masa 418,398 g/mol
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SB-612,111 je ligand opioidnog receptora. On je potentan i selektivan antagonist za nociceptinskog receptora (ORL-1). Ovaj ligand je nekoliko puta potentniji od starijeg leka J-113,397.[1] On ne proizvodi analgetičke efekte, nego sprečava razvoj hiperalgezije.[2] Pokazano je da ima antidepresivno dejstvo u studijama na životinjama.[3]

Vidi još[уреди]

Reference[уреди]

  1. Spagnolo, B; Carrà, G; Fantin, M; Fischetti, C; Hebbes, C; McDonald, J; Barnes, TA; Rizzi, A; Trapella, C (2007). „Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vitro studies”. The Journal of pharmacology and experimental therapeutics. 321 (3): 961—7. PMID 17329552. doi:10.1124/jpet.106.116764. 
  2. Zaratin, PF; Petrone, G; Sbacchi, M; Garnier, M; Fossati, C; Petrillo, P; Ronzoni, S; Giardina, GA; Scheideler, MA (2004). „Modification of nociception and morphine tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)”. The Journal of pharmacology and experimental therapeutics. 308 (2): 454—61. PMID 14593080. doi:10.1124/jpet.103.055848. 
  3. Rizzi, A; Gavioli, EC; Marzola, G; Spagnolo, B; Zucchini, S; Ciccocioppo, R; Trapella, C; Regoli, D; Calò, G (2007). „Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 (-)-cis-1-methyl-7-4-(2,6-dichlorophenyl)piperidin-1-ylmethyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol: in vivo studies”. The Journal of pharmacology and experimental therapeutics. 321 (3): 968—74. PMID 17329551. doi:10.1124/jpet.106.116780. 

Spoljašnje veze[уреди]

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