Tapentadol
 | |
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| Klinički podaci | |
|---|---|
| Prodajno ime | Nucynta, Palexia, TAPAL |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 4 h |
| Identifikatori | |
| CAS broj | 175591-23-8  |
| ATC kod | N02AX06 (WHO) |
| PubChem | CID 9838022 |
| DrugBank | DB06204 |
| ChemSpider | 8013742 |
| ChEMBL | CHEMBL1201776 |
| Hemijski podaci | |
| Formula | C14H23NO |
| Molarna masa | 221,339 |
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Tapentadol je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 221,339 Da.[1][2][3][4][5]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 2 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 5 |
| Particioni koeficijent[6] (ALogP) | 3,5 |
| Rastvorljivost[7] (logS, log(mol/L)) | -3,1 |
| Polarna površina[8] (PSA, Å2) | 23,5 |
Reference
[уреди | уреди извор]- ^ Tzschentke TM, Christoph T, Kogel B, Schiene K, Hennies HH, Englberger W, Haurand M, Jahnel U, Cremers TI, Friderichs E, De Vry J: (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties. J Pharmacol Exp Ther. Tzschentke, T. M.; Christoph, T.; Kögel, B.; Schiene, K.; Hennies, H. H.; Englberger, W.; Haurand, M.; Jahnel, U.; Cremers, T. I.; Friderichs, E.; De Vry, J. (2007 Oct). „(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (Tapentadol HCL): A novel mu-opioid receptor agonist/Norepinephrine reuptake inhibitor with broad-spectrum analgesic properties”. The Journal of Pharmacology and Experimental Therapeutics. 323 (1): 265—76. PMID 17656655. doi:10.1124/jpet.107.126052. Проверите вредност парамет(а)ра за датум:
|date=(помоћ). Epub 2007 Jul 26. - ^ Gohler K, Brett M, Smit JW, Rengelshausen J, Terlinden R: Comparative pharmacokinetics and bioavailability of tapentadol following oral administration of immediate- and prolonged-release formulations. Int J Clin Pharmacol Ther. Göhler, Karin; Brett, Martin; Smit, Johan W.; Rengelshausen, Jens; Terlinden, Rolf (2013 Apr). „Comparative pharmacokinetics and bioavailability of tapentadol following oral administration of immediate- and prolonged-release formulations”. Int. Journal of Clinical Pharmacology and Therapeutics. 51 (4): 338—348. PMID 23357834. doi:10.5414/CP201722. Проверите вредност парамет(а)ра за датум:
|date=(помоћ).. - ^ Xu XS, Smit JW, Lin R, Stuyckens K, Terlinden R, Nandy P: Population pharmacokinetics of tapentadol immediate release (IR) in healthy subjects and patients with moderate or severe pain. Clin Pharmacokinet. Xu, Xu Steven; Smit, Johan W.; Lin, Rachel; Stuyckens, Kim; Terlinden, Rolf; Nandy, Partha (2010 Oct). „Population Pharmacokinetics of Tapentadol Immediate Release (IR) in Healthy Subjects and Patients with Moderate or Severe Pain”. Clinical Pharmacokinetics. 49 (10): 671—682. PMID 20818833. doi:10.2165/11535390-000000000-00000. Проверите вредност парамет(а)ра за датум:
|date=(помоћ).. - ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ . doi:10.1021/jp980230o. Недостаје или је празан параметар
|title=(помоћ) - ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
