7-Spiroindaniloksimorfon

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7-Spiroindaniloksimorfon
7-Spiroindanyloxymorphone.svg
IUPAC ime
(4aR-(4aα,7aα,8α,9cα))- 1',3',7,7a,8,9- Hexahydro- 3,7a-dihydroxy- 12-methylspiro (6H-8,9c- (iminoethano) phenanthro (4,5-bcd) furan- 6,2'- (2H)inden)- 5(4aH)- one
Identifikatori
CAS broj 150380-34-0 ДаY
PubChem CID 5487084
ChemSpider 8176808 ДаY
Hemijski podaci
Formula C25H25NO4
Molarna masa 403.470 g/mol
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7-Spiroindaniloksimorfon (SIOM) je lek koji se koristi u naučnim istraživanjima. On je selektivni δ-opioidni agonist.[1][2][3][4][5]

Reference[уреди]

  1. Portoghese PS, Moe ST, Takemori AE (1993). „A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists”. Journal of medicinal chemistry. 36 (17): 2572—4. PMID 8394935. 
  2. Fang X, Larson DL, Portoghese PS (1997). „7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands”. Journal of medicinal chemistry. 40 (19): 3064—70. doi:10.1021/jm970283e. PMID 9301669. 
  3. Ohkawa S, Digiacomo B, Larson DL, Takemori AE, Portoghese PS (1997). „7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors”. Journal of medicinal chemistry. 40 (11): 1720—5. doi:10.1021/jm9700880. PMID 9171881. 
  4. Kshirsagar TA, Fang X, Portoghese PS (1998). „14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors”. Journal of medicinal chemistry. 41 (14): 2657—60. doi:10.1021/jm980209b. PMID 9651172. 
  5. Shenderovich MD, Liao S, Qian X, Hruby VJ (2000). „A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands”. Biopolymers. 53 (7): 565—80. doi:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5. PMID 10766952. 

Spoljašnje veze[уреди]

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