Секретин

Из Википедије, слободне енциклопедије
Секретин
Идентификатори
Симбол SCT
Вањски ИД OMIM182099 MGI99466 HomoloGene7928 GeneCards: SCT Gene
Ортолози
Врста Човек Миш
Ентрез 6343 20287
Eнсембл ENSG00000070031 ENSMUSG00000038580
UниПрот P09683 Q08535
Реф. Секв. (иРНК) NM_021920 NM_011328
Реф. Секв. (протеин) NP_068739 NP_035458
Локација (УЦСЦ) Chr 11:
0.62 - 0.62 Mb
Chr 7:
148.46 - 148.47 Mb
ПубМед претрага [1] [2]
Секретин
Идентификатори
Симбол SCT
Ентрез 6343
Хуго 10607
ОМИМ 182099
РефСек NM_021920
УниПрот P09683
Други подаци
Локус Хром. 11 p15.5

Секретин је хормон дигестивног система који луче С ћелије дванаестопалачног црева, стимулише секрецију течности богатих бикарбонатима из панкреаса и јетре.[1][2]

Извори[уреди]

  1. Häcki WH (1980). „Secretin”. Clin Gastroenterol 9 (3): 609—32. PMID 7000396. 
  2. Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S (2000). „Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA”. Cytogenet. Cell Genet. 90 (1-2): 47—52. doi:10.1159/000015658. PMID 11060443. 

Додатна литература[уреди]

  • Saus E, Brunet A, Armengol L; et al. (2010). „Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.”. Journal of psychiatric research 44 (14): HASH(0x117c470). doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908. 
  • Bertenshaw GP, Turk BE, Hubbard SJ; et al. (2001). „Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.”. J. Biol. Chem. 276 (16): 13248—55. doi:10.1074/jbc.M011414200. PMID 11278902. 
  • Lee LT, Lam IP, Chow BK (2008). „A functional variable number of tandem repeats is located at the 5' flanking region of the human secretin gene plays a downregulatory role in expression.”. J. Mol. Neurosci. 36 (1-3): 125—31. doi:10.1007/s12031-008-9083-5. PMID 18566919. 
  • Nussdorfer GG, Bahçelioglu M, Neri G, Malendowicz LK (2000). „Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis.”. Peptides 21 (2): 309—24. doi:10.1016/S0196-9781(99)00193-X. PMID 10764961. 
  • Lossi L, Bottarelli L, Candusso ME; et al. (2004). „Transient expression of secretin in serotoninergic neurons of mouse brain during development.”. Eur. J. Neurosci. 20 (12): 3259—69. doi:10.1111/j.1460-9568.2004.03816.x. PMID 15610158. 
  • Lee SM, Yung WH, Chen L, Chow BK (2005). „Expression and spatial distribution of secretin and secretin receptor in human cerebellum.”. Neuroreport 16 (3): 219—22. doi:10.1097/00001756-200502280-00003. PMID 15706223. 
  • Lam IP, Lee LT, Choi HS; et al. (2009). „Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP).”. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G90—7. doi:10.1152/ajpgi.00094.2009. PMC 2711755. PMID 19372104. 
  • Yamagata T, Aradhya S, Mori M; et al. (2002). „The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism.”. Genomics 80 (2): 185—94. doi:10.1006/geno.2002.6814. PMID 12160732. 
  • Lee LT, Tan-Un KC, Chow BK (2006). „Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1.”. Ann. N. Y. Acad. Sci. 1070: 393—8. doi:10.1196/annals.1317.051. PMID 16888198. 
  • Onori P, Wise C, Gaudio E; et al. (2010). „Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.”. Int. J. Cancer 127 (1): 43—54. doi:10.1002/ijc.25028. PMID 19904746. 
  • Lee LT, Tan-Un KC, Pang RT; et al. (2004). „Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.”. Mol. Endocrinol. 18 (7): 1740—55. doi:10.1210/me.2003-0461. PMID 15118068. 
  • Lu Y, Owyang C (2009). „Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways.”. Neurogastroenterol. Motil. 21 (7): 754—e47. doi:10.1111/j.1365-2982.2009.01271.x. PMC 2743409. PMID 19239625. 
  • Gandhi S, Rubinstein I, Tsueshita T, Onyuksel H (2002). „Secretin self-assembles and interacts spontaneously with phospholipids in vitro.”. Peptides 23 (1): 201—4. doi:10.1016/S0196-9781(01)00596-4. PMID 11814635. 
  • Love JW (2008). „Peptic ulceration may be a hormonal deficiency disease.”. Med. Hypotheses 70 (6): 1103—7. doi:10.1016/j.mehy.2007.12.011. PMID 18280672. 
  • Lam IP, Lee LT, Choi HS, Chow BK (2006). „Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells.”. Ann. N. Y. Acad. Sci. 1070: 371—5. doi:10.1196/annals.1317.047. PMID 16888194. 
  • Luttrell LM (2008). „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol. 39 (3): 239—64. doi:10.1007/s12033-008-9031-1. PMID 18240029. 
  • Du K, Couvineau A, Rouyer-Fessard C; et al. (2002). „Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding.”. J. Biol. Chem. 277 (40): 37016—22. doi:10.1074/jbc.M203049200. PMID 12133828. 
  • Portela-Gomes GM, Johansson H, Olding L, Grimelius L (1999). „Co-localization of neuroendocrine hormones in the human fetal pancreas.”. Eur. J. Endocrinol. 141 (5): 526—33. doi:10.1530/eje.0.1410526. PMID 10576771. 
  • Mutoh H, Ratineau C, Ray S, Leiter AB (2000). „Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells.”. Aliment. Pharmacol. Ther. 14 Suppl 1: 170—5. PMID 10807420.