Horionski gonadotropin alfa

Glikoproteinski hormoni, alfa polipeptid
Glikoproteinski hormoni, alfa polipeptid
	PDB prikaz baziran na 1dz7.
Dostupne strukture
	1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9
Identifikatori
Simboli	CGA; CG-ALPHA; FSHA; GPHA1; GPHa; HCG; LHA; TSHA
Vanjski ID	OMIM: 118850 MGI: 88390 HomoloGene: 587 GeneCards: CGA Gene
Ontologija gena
Molekularna funkcija	• hormonska aktivnost; • proteinsko vezivanje;
Celularna komponenta	• ekstracelularni region;
Biološki proces	• formiranje tiroidnog hormona; • prenos signala; • međućelijska signalizacija; • pozitivna regulacija ćelijske proliferacije; • razvoj gonade;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	1081
Ensembl	ENSG00000135346
UniProt	P01215
RefSeq (mRNA)	NM_000735.3
RefSeq (protein)	NP_000726.1
Lokacija (UCSC)	Chr 6:; 87.8 - 87.8 Mb
PubMed pretraga	[1]

Alfa lanac glikoproteinskih hormona je protein koji je kod ljudi kodiran CGA genom.^[1]

Četiri ljudska glikoproteinska hormona: humani horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulišući hormon (FSH), i tireostimulišući hormon (TSH) su dimeri koji se sastoje od alfa i beta podjedinica, koje su nekovalentno vezane. Alfa podjedinice tih hormona su skoro identične, dok su njihovi beta lanci jedinstveni i definišu biološku specifičnost. Protein kodiran ovim genom je alfa podjedinica i pripada familiji alfa lanaca glikoproteinskih hormona.^[2]

Alfa lanac ima sledeću aminokiselinsku sekvencu:

NH2 - Ala - Pro - Asp - Val - Gln - Asp - Cys - Pro - Glu - Cys - Thr - Leu - Gln - Glu - Asn - Pro - Phe - Phe - Ser - Gln - Pro - Gly - Ala - Pro - Ile - Leu - Gln - Cys - Met - Gly - Cys - Cys - Phe - Ser - Arg - Ala - Tyr - Pro - Thr - Pro - Leu - Arg - Ser - Lys - Lys - Thr - Met - Leu - Val - Gln - Lys - Asn - Val - Thr - Ser - Glu - Ser - Thr - Cys - Cys - Val - Ala - Lys - Ser - Tyr - Asn - Arg - Val - Thr - Val - Met - Gly - Gly - Phe - Lys - Val - Glu - Asn - His - Thr - Ala - Cys - His - Cys - Ser - Thr - Cys - Tyr - Tyr - His - Lys - Ser - COOH

Aminokiselinska sekvena beta lanaca je:

NH2 - Ser - Lys - Glu - Pro - Leu - Arg - Pro - Arg - Cys - Arg - Pro - Ile - Asn - Ala - Thr - Leu - Ala - Val - Glu - Lys - Glu - Gly - Cys - Pro - Val - Cys - Ile - Thr - Val - Asn - Thr - Thr - Ile - Cys - Ala - Gly - Tyr - Cys - Pro - Thr - Met - Thr - Arg - Val - Leu - Gln - Gly - Val - Leu - Pro - Ala - Leu - Pro - Gln - Val - Val - Cys - Asn - Tyr - Arg - Asp - Val - Arg - Phe - Glu - Ser - Ile - Arg - Leu - Pro - Gly - Cys - Pro - Arg - Gly - Val - Asn - Pro - Val - Val - Ser - Tyr - Ala - Val - Ala - Leu - Ser - Cys - Gln - Cys - Ala - Leu - Cys - Arg - Arg - Ser - Thr - Thr - Asp - Cys - Gly - Gly - Pro - Lys - Asp - His - Pro - Leu - Thr - Cys - Asp - Asp - Pro - Arg - Phe - Gln - Asp - Ser - Ser - Ser - Ser - Lys - Ala - Pro - Pro - Pro - Ser - Leu - Pro - Ser - Pro - Ser - Arg - Leu - Pro - Gly - Pro - Ser - Asp - Thr - Pro - Ile - Leu - Pro - Gln - COOH

Reference

^ Fiddes JC, Goodman HM (1982). „The gene encoding the common alpha subunit of the four human glycoprotein hormones”. J Mol Appl Genet. 1 (1): 3—18. PMID 6286817.
^ „Entrez Gene: CGA glycoprotein hormones, alpha polypeptide”.

Literatura

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Barrios-De-Tomasi J; Timossi C; Merchant H; et al. (2002). „Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones.”. Mol. Cell. Endocrinol. 186 (2): 189—98. PMID 11900895. doi:10.1016/S0303-7207(01)00657-8.
Moyle WR, Bahl OP, März L (1976). „Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action.”. J. Biol. Chem. 250 (23): 9163—9. PMID 172504.
Fiddes JC, Goodman HM (1979). „Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.”. Nature. 281 (5730): 351—6. PMID 481597. doi:10.1038/281351a0.
Sairam MR, Li CH (1977). „Human pituitary thyrotropin. The primary structure of the alpha and beta subunits.”. Can. J. Biochem. 55 (7): 755—60. PMID 890569. doi:10.1139/o77-108.
Morgan FJ, Birken S, Canfield RE (1975). „The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.”. J. Biol. Chem. 250 (13): 5247—58. PMID 1150658.
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Weisshaar G, Hiyama J, Renwick AG, Nimtz M (1991). „NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin.”. Eur. J. Biochem. 195 (1): 257—68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x.
Sakakibara R; Yokoo Y; Yoshikoshi K; et al. (1988). „Subcellular localization of intracellular forms of human chorionic gonadotropin in first trimester placenta.”. J. Biochem. 102 (5): 993—1001. PMID 2449427.
Matzuk MM, Keene JL, Boime I (1989). „Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction.”. J. Biol. Chem. 264 (5): 2409—14. PMID 2536708.
Lustbader JW; Birken S; Pileggi NF; et al. (1990). „Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states.”. Biochemistry. 28 (24): 9239—43. PMID 2611225. doi:10.1021/bi00450a001.
Harris DC; Machin KJ; Evin GM; et al. (1989). „Preliminary X-ray diffraction analysis of human chorionic gonadotropin.”. J. Biol. Chem. 264 (12): 6705—6. PMID 2708337.
Hayashizaki Y, Miyai K, Kato K, Matsubara K (1985). „Molecular cloning of the human thyrotropin-beta subunit gene.”. FEBS Lett. 188 (2): 394—400. PMID 3839756. doi:10.1016/0014-5793(85)80409-9.
Bellisario R, Carlsen RB, Bahl OP (1973). „Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit.”. J. Biol. Chem. 248 (19): 6796—809. PMID 4745444.
Shome B, Parlow AF (1974). „Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa).”. J. Clin. Endocrinol. Metab. 39 (1): 199—202. PMID 4835135. doi:10.1210/jcem-39-1-199.

[pmid6286817-1] Fiddes JC, Goodman HM (1982). „The gene encoding the common alpha subunit of the four human glycoprotein hormones”. J Mol Appl Genet. 1 (1): 3—18. PMID 6286817.

[2] „Entrez Gene: CGA glycoprotein hormones, alpha polypeptide”.

[1]

[2]