Moždani natriuretski peptid

Natriuretski peptid B
Natriuretski peptid B
Dostupne strukture
	1YK1, 3N56
Identifikatori
Simboli	NPPB; BNP
Vanjski ID	OMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene
Ontologija gena
Molekularna funkcija	• receptorsko vezivanje; • hormonska aktivnost; • aktivnost diuretiskog hormona;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor; • nukleus;
Biološki proces	• response to hipoksiju; • cGMP biosintetički proces; • inflamatorni respons;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	4879
Ensembl	ENSG00000120937
UniProt	P16860
RefSeq (mRNA)	NM_002521.2
RefSeq (protein)	NP_002512.1
Lokacija (UCSC)	Chr 1:; 11.92 - 11.92 Mb
PubMed pretraga	[1]

Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.^[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljudi ovaj hormon uglavnom proizvode srčane komore.

BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi

Reference

^ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

Literatura

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Spoljašnje veze

Brain+Natriuretic+Peptide на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

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