Rezistin

Rezistin
Rezistin
	Kristalografska struktura heksamera mišjeg rezistina (N-terminus = plavo, C-terminus = crveno).
Dostupne strukture
	1rfx, 1rgx
Identifikatori
Simboli	RETN; ADSF; FIZZ3; MGC126603; MGC126609; RETN1; RSTN; XCP1
Vanjski ID	OMIM: 605565 MGI: 1888506 HomoloGene: 10703 GeneCards: RETN Gene
Ontologija gena
Molekularna funkcija	• hormonska aktivnost;
Celularna komponenta	• ekstracelularni region;
Biološki proces	• biološki proces;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	56729
Ensembl	ENSG00000104918
UniProt	Q9HD89
RefSeq (mRNA)	NM_020415
RefSeq (protein)	NP_065148
Lokacija (UCSC)	Chr 19:; 7.64 - 7.64 Mb
PubMed pretraga	[1]

Rezistin (sekretorni faktor specifičan za adipozno tkivo, ADSF, (engl. C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein), XCP1) je protein bogat cisteinom koji je kod ljudi kodiran RETN genom.^[2]

Kod primata, svinja, i pasa, rezistin izlučuju imune i epitelne ćelije, dok ga kod glodara izlučuje adipozno tkivo. Dužina rezistinskog prepeptida kod ljudi je 108 aminokiselina, a kod miševa i pacova 114 aminokiselina. Molekulska masa je ~12.5 kDa. Rezistin je citokin čija fiziološka uloga je bila kontroverzna u pogledu njegovog uticaja na gojaznost i tip II dijabetes melitus.^[3]

Otkriće

Rezistin je otkrila grupa predvođena dr Mičelom Lazarom 2001 na Univerzitetu Pensilvanije u Školi za Medicinu.^[4] On je dobio ime „rezistin“ zato što je primećena insulinska rezistencija kod miševa nakon ubrizgavanja rezistina. Utvrđeno je da rezistin proizvodi i otpušta adipozno tkivo i da ima endokrine funkcije koje učestvuju u otpornosti na insulin. Ova ideja prvenstveno proizilazi iz sudija kojima je pokazano da se nivoi serumskog rezistina povećavaju sa gojaznošću u nekoliko model sistema (ljudi, pacovi, i miševi).^[4]^[5]^[6]^[7]^[8] U međuvremenu dalja istraživanja su povezala rezistin sa drugim fiziološkim sistemima kao što je inflamacija i energetska homeostaza.^[9]^[10]^[11]

Reference

^ PDB: 1rfx; Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L (2004). . „Disulfide-dependent multimeric assembly of resistin family hormones”. Science. 304 (5674): 1154—8. PMID 15155948. doi:10.1126/science.1093466.
^ Wang H, Chu WS, Hemphill C, Elbein SC (2002). . „Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians”. J. Clin. Endocrinol. Metab.. 87 (6): 2520—4. PMID 12050208. doi:10.1210/jc.87.6.2520.
^ Lazar MA (2007). . „Resistin- and Obesity-associated metabolic diseases”. Horm. Metab. Res.. 39 (10): 710—6. PMID 17952831. doi:10.1055/s-2007-985897.
^ ^а ^б Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001). . „The hormone resistin links obesity to diabetes”. Nature. 409 (6818): 307—12. PMID 11201732. doi:10.1038/35053000.
^ Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV (2003). . „Serum resistin (FIZZ3) protein is increased in obese humans”. J. Clin. Endocrinol. Metab.. 88 (11): 5452—5. PMID 14602788. doi:10.1210/jc.2002-021808.
^ Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (2002). . „Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?”. Diabetes. 51 (10): 2951—8. PMID 12351432. doi:10.2337/diabetes.51.10.2951.
^ Levy JR, Davenport B, Clore JN, Stevens W (2002). . „Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats”. Am. J. Physiol. Endocrinol. Metab.. 282 (3): E626—33. PMID 11832366. doi:10.1152/ajpendo.00346.2001.
^ McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar S (2002). . „Resistin, central obesity, and type 2 diabetes”. Lancet. 359 (9300): 46—7. PMID 11809189. doi:10.1016/S0140-6736(02)07281-1.
^ Adeghate E (2004). . „An update on the biology and physiology of resistin”. Cell. Mol. Life Sci.. 61 (19–20): 2485—96. PMID 15526156. doi:10.1007/s00018-004-4083-2.
^ Stumvoll M, Häring H (2002). . „Resistin and adiponectin--of mice and men”. Obes. Res.. 10 (11): 1197—9. PMID 12429885. doi:10.1038/oby.2002.162.
^ Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C (2004). . „Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity”. Obes. Res.. 12 (6): 962—71. PMID 15229336. doi:10.1038/oby.2004.118.

Spoljašnje veze

Resistin на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid15155948-1] PDB: 1rfx; Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L (2004). . „Disulfide-dependent multimeric assembly of resistin family hormones”. Science. 304 (5674): 1154—8. PMID 15155948. doi:10.1126/science.1093466.

[pmid12050208-2] Wang H, Chu WS, Hemphill C, Elbein SC (2002). . „Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians”. J. Clin. Endocrinol. Metab.. 87 (6): 2520—4. PMID 12050208. doi:10.1210/jc.87.6.2520.

[pmid17952831-3] Lazar MA (2007). . „Resistin- and Obesity-associated metabolic diseases”. Horm. Metab. Res.. 39 (10): 710—6. PMID 17952831. doi:10.1055/s-2007-985897.

[p30-4] а ^б Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001). . „The hormone resistin links obesity to diabetes”. Nature. 409 (6818): 307—12. PMID 11201732. doi:10.1038/35053000.

[p4-5] Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV (2003). . „Serum resistin (FIZZ3) protein is increased in obese humans”. J. Clin. Endocrinol. Metab.. 88 (11): 5452—5. PMID 14602788. doi:10.1210/jc.2002-021808.

[p8-6] Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (2002). . „Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?”. Diabetes. 51 (10): 2951—8. PMID 12351432. doi:10.2337/diabetes.51.10.2951.

[p16-7] Levy JR, Davenport B, Clore JN, Stevens W (2002). . „Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats”. Am. J. Physiol. Endocrinol. Metab.. 282 (3): E626—33. PMID 11832366. doi:10.1152/ajpendo.00346.2001.

[p19-8] McTernan CL, McTernan PG, Harte AL, Levick PL, Barnett AH, Kumar S (2002). . „Resistin, central obesity, and type 2 diabetes”. Lancet. 359 (9300): 46—7. PMID 11809189. doi:10.1016/S0140-6736(02)07281-1.

[p1-9] Adeghate E (2004). . „An update on the biology and physiology of resistin”. Cell. Mol. Life Sci.. 61 (19–20): 2485—96. PMID 15526156. doi:10.1007/s00018-004-4083-2.

[p31-10] Stumvoll M, Häring H (2002). . „Resistin and adiponectin--of mice and men”. Obes. Res.. 10 (11): 1197—9. PMID 12429885. doi:10.1038/oby.2002.162.

[p34-11] Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C (2004). . „Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity”. Obes. Res.. 12 (6): 962—71. PMID 15229336. doi:10.1038/oby.2004.118.

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