Beta polipeptid luteinizirajućeg hormona

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Beta polipeptid luteinizirajućeg hormona‎
Dostupne strukture
1M92
Identifikatori
Simboli LHB; CGB4; LSH-B; hLHB
Vanjski ID OMIM152780 MGI96782 HomoloGene81806 GeneCards: LHB Gene
Pregled RNK izražavanja
PBB GE LHB 214471 x at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3972 16866
Ensembl ENSG00000104826 ENSMUSG00000038194
UniProt P01229 Q3UUG9
RefSeq (mRNA) NM_000894.2 NM_008497.2
RefSeq (protein) NP_000885.1 NP_032523.2
Lokacija (UCSC) Chr 19:
49.52 - 49.52 Mb
Chr 7:
45.42 - 45.42 Mb
PubMed pretraga [1] [2]

Beta polipeptid luteinizirajućeg hormona (lutropinska podjedinica beta) je protein koji je kod ljudi kodiran LHB genom.[1][2]

Gen[уреди]

Geni beta lanaca horionskih gonadotropina i luteinizirajućeg hormona su dodirni na hromozomu 19q13.3.[2] Kod konja je ova podjedinica kodirana istim genom kao beta podjedinica horionskog gonadatropina.[3]

Funkcija[уреди]

Ovaj gen je član glikoproteinske familije hormonskih beta lanaca. On kodira beta podjedinicu luteinizirajućeg hormona (LH). Glikoproteinski hormoni su heterodimeri koji se sastoje od zajedničke alfa podjedinice i jedinstvene beta podjedinice (ovog proteina) koja im daje biološku specifičnost. LH je izražen u hipofizi. On promoviše spermatogenezu i ovulaciju putem stimulacije testisa i jajnika da sintetišu steroide.[2]

Klinički značaj[уреди]

Mutacije ovog gena su vezane za hipogonadizam koji je karakterisan neplodnošću i pseudohermafroditizmom.[2]

Reference[уреди]

  1. Sairam MR, Li CH (1976). „Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit”. Biochim Biophys Acta. 412 (1): 70—81. PMID 1191677. 
  2. 2,0 2,1 2,2 2,3 „Entrez Gene: LHB luteinizing hormone beta polypeptide”. 
  3. Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH (1992). „A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin”. Mol. Endocrinol. 6 (6): 951—9. doi:10.1210/me.6.6.951. PMID 1379674. 

Literatura[уреди]

  • Keutmann HT, Hua QX, Weiss MA (1992). „Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy”. Mol. Endocrinol. 6 (6): 904—13. doi:10.1210/me.6.6.904. PMID 1495492. 
  • Weiss J, Axelrod L, Whitcomb RW; et al. (1992). „Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone”. N. Engl. J. Med. 326 (3): 179—83. doi:10.1056/NEJM199201163260306. PMID 1727547. 
  • Weisshaar G, Hiyama J, Renwick AG, Nimtz M (1991). „NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin”. Eur. J. Biochem. 195 (1): 257—68. doi:10.1111/j.1432-1033.1991.tb15702.x. PMID 1991473. 
  • Jameson JL, Lindell CM, Habener JF (1986). „Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes”. DNA. 5 (3): 227—34. doi:10.1089/dna.1986.5.227. PMID 2424697. 
  • Keutmann HT, Charlesworth MC, Mason KA; et al. (1987). „A receptor-binding region in human choriogonadotropin/lutropin beta subunit”. Proc. Natl. Acad. Sci. U.S.A. 84 (7): 2038—42. doi:10.1073/pnas.84.7.2038. PMC 304579слободно за читање. PMID 3470775. 
  • Shome B, Parlow AF (1973). „The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH)”. J. Clin. Endocrinol. Metab. 36 (3): 618—21. doi:10.1210/jcem-36-3-618. PMID 4685398. 
  • Closset J, Hennen G, Lequin RM (1973). „Human luteinizing hormone. The amino acid sequence of the subunit”. FEBS Lett. 29 (2): 97—100. doi:10.1016/0014-5793(73)80534-4. PMID 4719207. 
  • Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). „Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone”. Nature. 307 (5946): 37—40. doi:10.1038/307037a0. PMID 6690982. 
  • Beitins IZ, Axelrod L, Ostrea T; et al. (1981). „Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone”. J. Clin. Endocrinol. Metab. 52 (6): 1143—9. doi:10.1210/jcem-52-6-1143. PMID 6785294. 
  • Berger P, Kranewitter W, Madersbacher S; et al. (1994). „Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis”. FEBS Lett. 343 (3): 229—33. doi:10.1016/0014-5793(94)80561-X. PMID 7513655. 
  • Keutmann HT, Rubin DA (1993). „A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking”. Endocrinology. 132 (3): 1305—12. doi:10.1210/en.132.3.1305. PMID 7679977. 
  • Herrlich A, Kühn B, Grosse R; et al. (1996). „Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C”. J. Biol. Chem. 271 (28): 16764—72. doi:10.1074/jbc.271.28.16764. PMID 8663226. 
  • Muyan M, Furuhashi M, Sugahara T, Boime I (1997). „The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers”. Mol. Endocrinol. 10 (12): 1678—87. doi:10.1210/me.10.12.1678. PMID 8961276. 
  • Roy AC, Liao WX, Chen Y; et al. (1997). „Identification of seven novel mutations in LH beta-subunit gene by SSCP”. Mol. Cell. Biochem. 165 (2): 151—3. PMID 8979264. 
  • Liao WX, Roy AC, Chan C; et al. (1998). „A new molecular variant of luteinizing hormone associated with female infertility”. Fertil. Steril. 69 (1): 102—6. doi:10.1016/S0015-0282(97)00445-7. PMID 9457942. 
  • O'Connor JF, Kovalevskaya G, Birken S; et al. (1998). „The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay”. Hum. Reprod. 13 (4): 826—35. doi:10.1093/humrep/13.4.826. PMID 9619532. 
  • Takahashi K, Kurioka H, Ozaki T; et al. (1999). „Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients”. Hum. Reprod. 13 (12): 3338—44. doi:10.1093/humrep/13.12.3338. PMID 9886510. 
  • Elter K, Erel CT, Cine N; et al. (1999). „Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome”. Fertil. Steril. 71 (3): 425—30. doi:10.1016/S0015-0282(98)00491-9. PMID 10065776. 
  • Jiang M, Pakarinen P, Zhang FP; et al. (1999). „A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence”. Hum. Mol. Genet. 8 (11): 2037—46. doi:10.1093/hmg/8.11.2037. PMID 10484773.