Timopoietin

Из Википедије, слободне енциклопедије
Timopoietin
PDB prikaz baziran na 1gjj.
Dostupne strukture
1GJJ, 1H9E, 1H9F
Identifikatori
Simboli TMPO; CMD1T; LAP2; LEMD4; PRO0868; TP
Vanjski ID OMIM188380 MGI106920 HomoloGene31144 GeneCards: TMPO Gene
Pregled RNK izražavanja
PBB GE TMPO 209753 s at tn.png
PBB GE TMPO 209754 s at tn.png
PBB GE TMPO 203432 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7112 21917
Ensembl ENSG00000120802 ENSMUSG00000019961
UniProt P42166 Q61029
RefSeq (mRNA) NM_001032283.2 NM_001080129.1
RefSeq (protein) NP_001027454.1 NP_001073598.1
Lokacija (UCSC) Chr 12:
98.91 - 98.94 Mb
Chr 10:
91.15 - 91.17 Mb
PubMed pretraga [1] [2]

Timopoietin (polipeptid vezan za laminu 2, LAP2) je protein koji je kod ljudi kodiran TMPO genom.[1][2] LAP2 je protein unutrašnje membrane jedra.[3]

Timopoietin učestvuje u indukciji CD90 proteina u grudnu žlezdu. Gen timopoetina kodira tri alternativno splajsovane iRNK molekula koji kodiraju proteine sa 75 kDa (alfa), 51 kDa (beta) i 39 kDa (gama). Oni su izraženi u većini ćelijskih tipova. Ljudski TMPO gen se nalazi u hromozomsko opsegu 12q22 i sastoji se od osam eksona.

Interakcije[уреди]

Timopoietin formira interakcije sa barijerom za autointegracioni faktor 1,[4] AKAP8L,[5][6] LMNB1[7][8] i LMNA.[9][10]

Reference[уреди]

  1. Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (1994). „Three distinct human thymopoietins are derived from alternatively spliced mRNAs”. Proc Natl Acad Sci U S A 91 (14): 6283—7. doi:10.1073/pnas.91.14.6283. PMC 44185. PMID 7517549. 
  2. „Entrez Gene: TMPO thymopoietin”. 
  3. PMID 11766875 (PubMed)
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  4. Furukawa, K (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction”. J. Cell. Sci. (ENGLAND) 112 (15): 2485—92. ISSN 0021-9533. PMID 10393804. 
  5. Martins, S B; Eide T, Steen R L, Jahnsen T, Skålhegg B S, Collas P (2000). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics”. J. Cell. Sci. (ENGLAND) 113 (21): 3703—13. ISSN 0021-9533. PMID 11034899. 
  6. Martins, Sandra; Eikvar Sissel, Furukawa Kazuhiro, Collas Philippe (2003). „HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication”. J. Cell Biol. (United States) 160 (2): 177—88. doi:10.1083/jcb.200210026. ISSN 0021-9525. PMC 2172640. PMID 12538639. 
  7. Furukawa, K; Kondo T (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin”. Eur. J. Biochem. (GERMANY) 251 (3): 729—33. doi:10.1046/j.1432-1327.1998.2510729.x. ISSN 0014-2956. PMID 9490046. 
  8. Foisner, R; Gerace L (1993). „Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation”. Cell (UNITED STATES) 73 (7): 1267—79. doi:10.1016/0092-8674(93)90355-T. ISSN 0092-8674. PMID 8324822. 
  9. Markiewicz, Ewa; Dechat Thomas, Foisner Roland, Quinlan Roy A, Hutchison Christopher J (2002). „Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein”. Mol. Biol. Cell (United States) 13 (12): 4401—13. doi:10.1091/mbc.E02-07-0450. ISSN 1059-1524. PMC 138642. PMID 12475961. 
  10. Dechat, T; Korbei B, Vaughan O A, Vlcek S, Hutchison C J, Foisner R (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins”. J. Cell. Sci. (ENGLAND) 113 (19): 3473—84. ISSN 0021-9533. PMID 10984438. 

Literatura[уреди]

  • Harris CA, Andryuk PJ, Cline SW, Mathew S, Siekierka JJ, Goldstein G (1995). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2”. Genomics 28 (2): 198—205. doi:10.1006/geno.1995.1131. PMID 8530026. 
  • Dechat T, Vlcek S, Foisner R (2000). „Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics.”. J. Struct. Biol. 129 (2-3): 335—45. doi:10.1006/jsbi.2000.4212. PMID 10806084. 
  • Twomey JJ, Goldstein G, Lewis VM; et al. (1977). „Bioassay determinations of thymopoietin and thymic hormone levels in human plasma.”. Proc. Natl. Acad. Sci. U.S.A. 74 (6): 2541—5. doi:10.1073/pnas.74.6.2541. PMC 432209. PMID 302007. 
  • Heavner GA, Audhya T, Goldstein G (1990). „Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines.”. Regul. Pept. 27 (2): 257—62. doi:10.1016/0167-0115(90)90044-W. PMID 2158125. 
  • Fuccello A, Audhya T, Talle MA, Goldstein G (1984). „Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies.”. Arch. Biochem. Biophys. 228 (1): 292—8. doi:10.1016/0003-9861(84)90070-5. PMID 6364989. 
  • Hara H, Hayashi K, Ohta K; et al. (1995). „A new thymopoietin precursor gene from human thymus.”. Biochem. Mol. Biol. Int. 34 (5): 927—33. PMID 7703909. 
  • Goldstein G, Schlesinger DH, Audhya T (1994). „Isolation and complete amino acid sequence of human thymopoietin and splenin.”. Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6249. doi:10.1073/pnas.91.13.6249. PMC 44176. PMID 8016147. 
  • Harris CA, Andryuk PJ, Cline SW; et al. (1996). „Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2.”. Genomics 28 (2): 198—205. doi:10.1006/geno.1995.1131. PMID 8530026. 
  • Andersson B, Wentland MA, Ricafrente JY; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Berger R, Theodor L, Shoham J; et al. (1996). „The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products.”. Genome Res. 6 (5): 361—70. doi:10.1101/gr.6.5.361. PMID 8743987. 
  • Yu W, Andersson B, Worley KC; et al. (1997). „Large-scale concatenation cDNA sequencing.”. Genome Res. 7 (4): 353—8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Furukawa K, Fritze CE, Gerace L (1998). „The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain.”. J. Biol. Chem. 273 (7): 4213—9. doi:10.1074/jbc.273.7.4213. PMID 9461618. 
  • Furukawa K, Kondo T (1998). „Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin.”. Eur. J. Biochem. 251 (3): 729—33. doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046. 
  • Dechat T, Gotzmann J, Stockinger A; et al. (1998). „Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics.”. EMBO J. 17 (16): 4887—902. doi:10.1093/emboj/17.16.4887. PMC 1170818. PMID 9707448. 
  • Furukawa K (1999). „LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction.”. J. Cell. Sci. 112 (15): 2485—92. PMID 10393804. 
  • Weber PJ, Eckhard CP, Gonser S; et al. (1999). „On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family.”. Biol. Chem. 380 (6): 653—60. doi:10.1515/BC.1999.081. PMID 10430029. 
  • Dechat T, Korbei B, Vaughan OA; et al. (2000). „Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins.”. J. Cell. Sci. 113 (19): 3473—84. PMID 10984438. 
  • Martins SB, Eide T, Steen RL; et al. (2001). „HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics.”. J. Cell. Sci. 113 (21): 3703—13. PMID 11034899. 

Spoljašnje veze[уреди]