Edaravon

Из Википедије, слободне енциклопедије
Edaravon
Edaravone.png
IUPAC ime
5-metil-2-fenil-2,4-dihidro-3H-pirazol-3-on
Klinički podaci
Način primene Oralno
Pravni status
Pravni status
  • ℞ (Prescription only)
Identifikatori
CAS broj 89-25-8 ДаY
ATC kod none
PubChem CID 4021
ChemSpider 3881 ДаY
UNII S798V6YJRP ДаY
KEGG D01552 ДаY
ChEBI CHEBI:31530 ДаY
ChEMBL CHEMBL290916 ДаY
Sinonimi MCI-186
Hemijski podaci
Formula C10H10N2O
Molarna masa 174,20 g/mol
  (verify)

Edaravon (Radicut) je neuroprotektivni lek koji pomaže u neurološkom oporavku nakon akutne ishemije mozga i naknadne cerebralne infarkcije.[1] On deluje kao potentan antioksidans i jak sakupljaš slobodnih radikala, koji štiti od oksidativnog stresa i neuronalne apoptoze.[2][3][4] On je u prodaji u Japanu (od 2001.)[1] i u Indiji.

Edaravon umanjuje dejstvo metamfetamina i 6-OHDA indukovanu dopaminergičku neurotoksičnost u strijatumu i substantia nigra, a nema efekta na metamfetaminom indukovano otpuštanje dopamina ili hipertermiju.[5][6] On takođe štiti protiv MPTP-posredovane dopaminergičke neurotoksičnosti u substantia nigra, mada ne i u strijatumu.[7][8][9]

Reference[уреди]

  1. 1,0 1,1 Doherty, Annette M. (2002). Annual Reports in Medicinal Chemistry, Volume 37 (Annual Reports in Medicinal Chemistry). Boston: Academic Press. ISBN 978-0-12-040537-4. 
  2. Watanabe T, Tanaka M, Watanabe K, Takamatsu Y, Tobe A (2004). „[Research and development of the free radical scavenger edaravone as a neuroprotectant]”. Yakugaku Zasshi (на језику: Japanese) 124 (3): 99—111. PMID 15049127. 
  3. Higashi Y, Jitsuiki D, Chayama K, Yoshizumi M (2006). „Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases”. Recent Patents on Cardiovascular Drug Discovery 1 (1): 85—93. PMID 18221078. 
  4. Yoshida H, Yanai H, Namiki Y, Fukatsu-Sasaki K, Furutani N, Tada N (2006). „Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury”. CNS Drug Reviews 12 (1): 9—20. doi:10.1111/j.1527-3458.2006.00009.x. PMID 16834755. 
  5. Yuan WJ, Yasuhara T, Shingo T; et al. (2008). „Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons”. BMC Neuroscience 9: 75. doi:10.1186/1471-2202-9-75. PMC 2533664. PMID 18671880. 
  6. Kawasaki T, Ishihara K, Ago Y; et al. (2006). „Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum”. European Journal of Pharmacology 542 (1-3): 92—9. doi:10.1016/j.ejphar.2006.05.012. PMID 16784740. 
  7. Kawasaki T, Ishihara K, Ago Y, Baba A, Matsuda T (2007). „Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum”. The Journal of Pharmacology and Experimental Therapeutics 322 (1): 274—81. doi:10.1124/jpet.106.119206. PMID 17429058. 
  8. Yokoyama H, Takagi S, Watanabe Y, Kato H, Araki T (2008). „Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice”. Journal of Neural Transmission (Vienna, Austria : 1996) 115 (6): 831—42. doi:10.1007/s00702-008-0019-6. PMID 18235988. 
  9. Yokoyama H, Yano R, Aoki E, Kato H, Araki T (2008). „Comparative pharmacological study of free radical scavenger, nitric oxide synthase inhibitor, nitric oxide synthase activator and cyclooxygenase inhibitor against MPTP neurotoxicity in mice”. Metabolic Brain Disease 23 (3): 335—49. doi:10.1007/s11011-008-9096-3. PMID 18648914. 

Literatura[уреди]

Spoljašnje veze[уреди]


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