A-349,821

A-349,821
IUPAC ime
	(4'-[3-(2R,5R-dimetilpirolidin-1-il)propoksi]bifenil-4-il)morfolin-4-ilmetanon
Identifikatori
CAS broj	372513-99-0
ATC kod	none
PubChem	CID 9954017
IUPHAR/BPS	1217
ChemSpider	8129627
ChEMBL	CHEMBL179702
Hemijski podaci
Formula	C26H34N2O3
Molarna masa	422,558
	SMILES C[C@@H]1CC[C@H](N1CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)N4CCOCC4)C; ;
	InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m1/s1 ; Key:CFUHKRLMDNFZED-NHCUHLMSSA-N ;

A-349,821 je potentan i selektivan antagonist histaminskog H₃ receptora^[1] (a verovatno i inverzni agonist).^[2] Pokazano je da ima nootropno dejstvo u životinjskim studijama.^[3] Ovo jedinjenje se koristi u laboratorijskim istraživanjima.

Reference[uredi | uredi izvor]

^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K; Bennani, YL (2003). „Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists”. Bioorganic & Medicinal Chemistry Letters. 13 (7): 1325—8. PMID 12657274. doi:10.1016/S0960-894X(03)00118-5.
^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW; Esbenshade, TA (2006). „Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand”. British Journal of Pharmacology. 148 (5): 657—70. PMC 1751875 . PMID 16715122. doi:10.1038/sj.bjp.0706752.
^ Esbenshade, TA; Fox, GB; Krueger, KM; Baranowski, JL; Miller, TR; Kang, CH; Denny, LI; Witte, DG; Yao, BB (2004). „Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist”. Biochemical pharmacology. 68 (5): 933—45. PMID 15294456. doi:10.1016/j.bcp.2004.05.048.