VUF-8430

Из Википедије, слободне енциклопедије
VUF-8430
Skeletal formula of VUF-8430
Nazivi
Preferisani IUPAC naziv
2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
Identifikacija
3D model (Jmol)
Abrevijacija VUF-8430
ChemSpider
Svojstva
C4H11N5S
Molarna masa 161,23 g·mol−1
log P -1,367
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

VUF-8430 je histaminski agonist[3] koji je selektivan za H4 tip receptora.[4]

Reference[уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). „Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury”. Neuroimmunomodulation. 14 (6): 317—25. doi:10.1159/000125048. PMID 18401194. 
  4. Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). „Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.”. Journal of Medical Chemistry. 49 (23): 6650—1. doi:10.1021/jm060880d. PMID 17154494. 

Spoljašnje veze[уреди]