JNJ 7777120

Из Википедије, слободне енциклопедије
JNJ 7777120
(IUPAC) ime
5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-indol
Klinički podaci
Identifikatori
CAS broj 459168-41-3
ATC kod nije dodeljen
PubChem[1][2] 4908365
ChEMBL[3] CHEMBL129198 YesY
Hemijski podaci
Formula C14H16ClN3O 
Mol. masa 277,749 g/mol
SMILES eMolekuli & PubHem
Sinonimi 1-[(5-hloro-1H-indol-2-il)karbonil]-4-metilpiperazin
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

JNJ-7777120 je lek koji je razvila kompanija Džonson & Džonson. On deluje kao potentan i selektivan antagonist histaminskog H4 receptora.[4] On ima antiinflamatorno dejstvo.[5] Pokazano je da je superioran u odnosu na traditionalne antihistamine u treatmanu pruritusa (svraba).[6]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ^ Jiang W, Lim HD, Zhang M, et al. (July 2008). „Cloning and pharmacological characterization of the dog histamine H(4) receptor“. Eur. J. Pharmacol. 592 (1–3): 26–32. DOI:10.1016/j.ejphar.2008.06.095. PMID 18639542. 
  5. ^ Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics. 2004 Apr;309(1):404-13. PMID 14722321
  6. ^ Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D, Thurmond RL. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. Journal of Allergy and Clinical Immunology. 2007 Jan;119(1):176-83. PMID 17208599

Spoljašnje veze[уреди]