Konesin

Konesin
Nazivi
	Drugi nazivi N,N-Dimetil-kon-5-enin-3-amin
Identifikacija
CAS broj	546-06-5 ;
3D model (Jmol)	interaktivna slika;
ECHA InfoCard	100.008.089
MeSH	Conessine
PubChem C ID	2860;
	SMILES C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C; ; ; ; ; ;
Svojstva
Hemijska formula	C24H40N2
Molarna masa	356,5878
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Konesin je steroidni alkaloid prisutan u brojnim biljnim vrstama iz Apocynaceae familije, uključujući Holarrhena floribunda,^[3] Holarrhena antidysenterica^[4] i Funtumia elastica,^[5] neke od kojih se koriste u tradicionalnom travarstvu kao tretman za amebnu dizenteriju.^[6] On deljuje kao histaminski antagonist, koji je selektivan za H₃ receptor.^[7]

Reference[уреди | уреди извор]

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993
^ Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193
^ Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333
^ Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597
^ Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

Spoljašnje veze[уреди | уреди извор]

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993

[4] Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193

[5] Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333

[6] Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597

[7] Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

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