Kuiskualinska kiselina

С Википедије, слободне енциклопедије
Kuiskualinska kiselina
Nazivi
IUPAC naziv
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Identifikacija
ECHA InfoCard 100.164.809
MeSH Quisqualic+Acid
Svojstva
C5H7N3O5
Molarna masa 189,126 g/mol
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Reference infokutije

Kuiskualinska kiselina je agonist AMPA receptora i grupe I metabotropskih glutamatnih receptora.[3][4][5] Ona uzrokuje ekscitotoksičnost i koristi se u neurologiji za selektivno uništavanje neurona mozga i kičmene moždine.[6][7][8]

Reference[уреди | уреди извор]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  2. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. ^ Jin, R.; Horning, M.; Mayer, M. L.; Gouaux, E. (2002). „Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate”. Biochemistry. 41 (52): 15635—43. PMID 12501192. doi:10.1021/bi020583k. 
  4. ^ Kuang, D.; Hampson, D. R. (2006). „Ion dependence of ligand binding to metabotropic glutamate receptors”. Biochemical and Biophysical Research Communications. 345 (1): 1—6. PMID 16674916. doi:10.1016/j.bbrc.2006.04.064. 
  5. ^ Zhang, W.; Robert, A.; Vogensen, S. B.; Howe, J. R. (2006). „The relationship between agonist potency and AMPA receptor kinetics”. Biophysical Journal. 91 (4): 1336—46. PMC 1518651Слободан приступ. PMID 16731549. doi:10.1529/biophysj.106.084426. 
  6. ^ Muir, J. L.; Page, K. J.; Sirinathsinghji, D. J.; Robbins, T. W.; Everitt, B. J. (1993). „Excitotoxic lesions of basal forebrain cholinergic neurons: Effects on learning, memory and attention”. Behavioural Brain Research. 57 (2): 123—31. PMID 7509608. S2CID 3994174. doi:10.1016/0166-4328(93)90128-d. 
  7. ^ Giovannelli L, Casamenti F, Pepeu G. Journal of Neural Transmission. 1998;105(8-9):935-48. „C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.”. PMID 9869327. 
  8. ^ Lee, J. W.; Furmanski, O.; Castellanos, D. A.; Daniels, L. A.; Hama, A. T.; Sagen, J. (2008). „Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury”. Neuroscience Letters. 439 (2): 212—5. PMC 2680189Слободан приступ. PMID 18524486. doi:10.1016/j.neulet.2008.05.030. 

Vidi još[уреди | уреди извор]

Spoljašnje veze[уреди | уреди извор]