3-MeO-PCMo
 | |
| IUPAC ime | |
|---|---|
4-[1-(3-metoksifenil)cikloheksil]morfolin | |
| Pravni status | |
| Pravni status |
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| Identifikatori | |
| CAS broj | 138873-80-0 |
| PubChem | CID 132605908 |
| ChemSpider | 58191437 |
| UNII | 96QW73BA62 |
| Hemijski podaci | |
| Formula | C17H25NO2 |
| Molarna masa | 275,39 g·mol−1 |
| |
| |
3-MeO-PCMo je disocijativni anestetik koji je po strukturi sličan fenciklidinu[1][2] i koji se prodaje onlajn kao dizajnirana droga.[3][4] Inhibitorni efekat 3-MeO-PCMo na smanjenje gustine klastera drebrina NMDAR stimulacijom glutaminskom kiselinom je niži od PCP-a ili 3-MeO-PCP, sa polovinom maksimalne inhibitorne koncentracije (IC50) od 26,67 μM (3-MeO-PCMo), 2,02 μM (PCP) i 1,51 μM (3-MeO-PCP).[5]
Reference[уреди | уреди извор]
- ^ Ahmadi A, Khalili M, Hajikhani R, Naserbakht M (април 2011). „New morpholine analogues of phencyclidine: chemical synthesis and pain perception in rats”. Pharmacology, Biochemistry, and Behavior. 98 (2): 227—33. PMID 21215770. S2CID 24650035. doi:10.1016/j.pbb.2010.12.019.
- ^ Abiero A, Botanas CJ, Custodio RJ, Sayson LV, Kim M, Lee HJ, et al. (март 2020). „4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels”. Psychopharmacology. 237 (3): 757—772. PMID 31828394. S2CID 209169410. doi:10.1007/s00213-019-05412-y.
- ^ Colestock T, Wallach J, Mansi M, Filemban N, Morris H, Elliott SP, et al. (фебруар 2018). „Syntheses, analytical and pharmacological characterizations of the 'legal high' 4-[1-(3-methoxyphenyl)cyclohexyl]morpholine (3-MeO-PCMo) and analogues”. Drug Testing and Analysis. 10 (2): 272—283. PMID 28513099. doi:10.1002/dta.2213.
- ^ „3-MeO-PCMo”. New Synthetic Drugs Database. Архивирано из оригинала 2016-07-03. г. Приступљено 2016-02-09.
- ^ Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T (2019). „Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay”. Journal of Pharmacological and Toxicological Methods. 99: 106583. PMID 31082488. doi:10.1016/j.vascn.2019.106583
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