Alazocin

Из Википедије, слободне енциклопедије
Alazocin
(IUPAC) ime
(2R,6R,11R)- 6,11-dimethyl- 3-prop- 2-en- 1-yl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol 2-allyl- 5,9-dimethyl- 2'-hydroxy- 6,7-benzomorphan
Klinički podaci
Identifikatori
CAS broj 14198-28-8
ATC kod nije dodeljen
PubChem[1][2] 3036246
ChemSpider[3] 2300306
Hemijski podaci
Formula C17H23NO 
Mol. masa 257.37 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Uncontrolled
Način primene  ?

Alazocin ((-)-SKF-10,047, (-)-N-alilnormetazocin, (-)-ANMC), je bio prvi lek koji je agonist σ1 receptora (Ki = 24 nM).[4][5][6] On nema značajan afinitet za σ2 receptor.[6] Alazocin takođe deluje kao agonist κ-opioidnog receptora (Ki = 0.4 nM), i u znatno manjoj meri kao antagonist NMDA receptora (Ki = 587 nM).[6][7]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ^ Iwamoto ET (February 1981). „Pharmacologic effects of N-allylnormetazocine (SKF-10047)“. NIDA research monograph 34: 82–8. PMID 6783955. 
  5. ^ Shearman GT, Herz A (August 1982). „Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat“. European journal of pharmacology 82 (3-4): 167–72. PMID 6290235. 
  6. ^ а б в Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (March 1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan“. Brain Research 821 (2): 516–9. DOI:10.1016/S0006-8993(99)01125-7. PMID 10064839. 
  7. ^ Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J (2006). „Pharmacological profiles of opioid ligands at kappa opioid receptors“. BMC Pharmacology 6: 3. DOI:10.1186/1471-2210-6-3. PMC 1403760. PMID 16433932. 

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