Peptid YY

Peptid YY
Peptid YY
	PDB prikaz baziran na 1qbf.
Dostupne strukture
	1qbf, 1ru5, 1ruu, 2dez, 2df0
Identifikatori
Simboli	PYY; PYY1
Vanjski ID	OMIM: 600781 MGI: 99924 HomoloGene: 3066 GeneCards: PYY Gene
Ontologija gena
Molekularna funkcija	• hormonska aktivnost;
Celularna komponenta	• ekstracelularni region; • rastvorna frakcija;
Biološki proces	• ćelijska motilnost; • organizacija i biogeneza citoskeletona; • signalni put G-protein spregnutog receptora; • ćelija-ćelija signalizacija; • varenje; • način ishrane; • ćelijska proliferacija;
Ortolozi
Vrsta	Čovek
Entrez	5697
Ensembl	ENSG00000131096
UniProt	P10082
RefSeq (mRNA)	NM_004160
RefSeq (protein)	NP_004151
Lokacija (UCSC)	Chr 17:; 39.39 - 39.44 Mb
PubMed pretraga	[1]

Peptid YY je kratak (36-aminokiselina) protein koga oslobađaju ćelije ileuma i debelo crevo u responsu na unos hrane. Kod ljudi on umanjuje apetit. On je takođe poznat kao PYY, peptid tirozin tirozin, ili pankreasni peptid YY_3-36.^[1]

Struktura[uredi | uredi izvor]

Peptid YY je srodan sa pankreasnom peptidnom familijom, jer je 18 od njegovih 36 aminokiselina locirano u istim pozicijama kao kod pankreasnog peptida.^[2] Postoje dve glavne forme peptide YY: PYY_1-36 i PYY_3-36 koji imaju PP strukturni motiv. Međutim, najčešća forma cirkulišućeg PYY je PYY_3-36, koja se vezuje za Y2 receptor (Y2R) Y familije receptora.^[3] Peptid YY_3-36 (PYY) je linearni polipeptid koji se sastoji od 36 aminokiselina.

Vidi još[uredi | uredi izvor]

Reference[uredi | uredi izvor]

^ „Entrez Gene: PYY peptide YY”.
^ DeGroot, Leslie Jacob (1989). J. E. McGuigan, ур. Endocrinology. Philadelphia: Saunders. стр. 2754. ISBN 0-7216-2888-5.
^ Murphy KG, Bloom SR (2006). „Gut hormones and the regulation of energy homeostasis”. Nature. 444 (7121): 854—9. PMID 17167473. doi:10.1038/nature05484.

Literatura[uredi | uredi izvor]

Ekblad E, Sundler F (2002). „Distribution of pancreatic polypeptide and peptide YY.”. Peptides. 23 (2): 251—61. PMID 11825640. doi:10.1016/S0196-9781(01)00601-5.
Sandström O, El-Salhy M (2002). „Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY.”. Peptides. 23 (2): 263—7. PMID 11825641. doi:10.1016/S0196-9781(01)00603-9.
Yang H (2002). „Central and peripheral regulation of gastric acid secretion by peptide YY.”. Peptides. 23 (2): 349—58. PMID 11825649. doi:10.1016/S0196-9781(01)00611-8.
Naruse S, Kitagawa M, Ishiguro H, Hayakawa T (2002). „Feedback regulation of pancreatic secretion by peptide YY.”. Peptides. 23 (2): 359—65. PMID 11825650. doi:10.1016/S0196-9781(01)00612-X.
Aponte GW (2002). „PYY-mediated fatty acid induced intestinal differentiation.”. Peptides. 23 (2): 367—76. PMID 11825651. doi:10.1016/S0196-9781(01)00613-1.
Hagan MM (2002). „Peptide YY: a key mediator of orexigenic behavior.”. Peptides. 23 (2): 377—82. PMID 11825652. doi:10.1016/S0196-9781(01)00614-3.
Mannon PJ (2002). „Peptide YY as a growth factor for intestinal epithelium.”. Peptides. 23 (2): 383—8. PMID 11825653. doi:10.1016/S0196-9781(01)00615-5.
Tseng WW, Liu CD (2002). „Peptide YY and cancer: current findings and potential clinical applications.”. Peptides. 23 (2): 389—95. PMID 11825654. doi:10.1016/S0196-9781(01)00616-7.
El-Salhy M, Suhr O, Danielsson A (2002). „Peptide YY in gastrointestinal disorders.”. Peptides. 23 (2): 397—402. PMID 11825655. doi:10.1016/S0196-9781(01)00617-9.
Imamura M (2002). „Effects of surgical manipulation of the intestine on peptide YY and its physiology.”. Peptides. 23 (2): 403—7. PMID 11825656. doi:10.1016/S0196-9781(01)00618-0.
Beglinger C, Degen L (2007). „Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?”. Physiol. Behav. 89 (4): 460—4. PMID 16828127. doi:10.1016/j.physbeh.2006.05.048.
Eberlein GA; Eysselein VE; Schaeffer M; et al. (1989). „A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).”. Peptides. 10 (4): 797—803. PMID 2587421. doi:10.1016/0196-9781(89)90116-2.
Facer P, Bishop AE, Cole GA; et al. (1989). „Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells.”. Gastroenterology. 97 (1): 48—57. PMID 2721879.
Tatemoto K; Nakano I; Makk G; et al. (1989). „Isolation and primary structure of human peptide YY.”. Biochem. Biophys. Res. Commun. 157 (2): 713—7. PMID 3202875. doi:10.1016/S0006-291X(88)80308-5.
Lukinius AI, Ericsson JL, Lundqvist MK, Wilander EM (1986). „Ultrastructural localization of serotonin and polypeptide YY (PYY) in endocrine cells of the human rectum.”. J. Histochem. Cytochem. 34 (6): 719—26. PMID 3517149.
Adrian TE; Ferri GL; Bacarese-Hamilton AJ; et al. (1985). „Human distribution and release of a putative new gut hormone, peptide YY.”. Gastroenterology. 89 (5): 1070—7. PMID 3840109.
Lundell I; Blomqvist AG; Berglund MM; et al. (1996). „Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.”. J. Biol. Chem. 270 (49): 29123—8. PMID 7493937. doi:10.1074/jbc.270.49.29123.
Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). „Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.”. J. Biol. Chem. 270 (45): 26762—5. PMID 7592911. doi:10.1074/jbc.270.45.26762.
Hort Y; Baker E; Sutherland GR; et al. (1995). „Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1.”. Genomics. 26 (1): 77—83. PMID 7782089. doi:10.1016/0888-7543(95)80085-Z.
Kohri K; Nata K; Yonekura H; et al. (1993). „Cloning and structural determination of human peptide YY cDNA and gene.”. Biochim. Biophys. Acta. 1173 (3): 345—9. PMID 8318545.
Batterham RL, Heffron H, Kapoor S, Chivers J, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ (2006). „Critical role for peptide YY in protein-mediated satiation and body-weight regulation.”. Cell Metabolism. 4 (3): 223—233. PMID 16950139. doi:10.1016/j.cmet.2006.08.001.
DeGroot, Leslie Jacob (1989). J. E. McGuigan, ур. Endocrinology. Philadelphia: Saunders.

Spoljašnje veze[uredi | uredi izvor]

Peptide+YY на US National Library of Medicine Medical Subject Headings (MeSH)

[entrez-1] „Entrez Gene: PYY peptide YY”.

[isbn0-7216-2888-5-2] DeGroot, Leslie Jacob (1989). J. E. McGuigan, ур. Endocrinology. Philadelphia: Saunders. стр. 2754. ISBN 0-7216-2888-5.

[pmid17167473-3] Murphy KG, Bloom SR (2006). „Gut hormones and the regulation of energy homeostasis”. Nature. 444 (7121): 854—9. PMID 17167473. doi:10.1038/nature05484.

[1]

[2]

[3]