Dekstrorfan

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Dekstrorfan
Dextrorphan.svg
Dextrorphane 3d.gif
IUPAC ime
(+)-17-methyl- 9a,13a,14a-morphinan- 3-ol
Pravni status
Pravni status
  • US: OTC
Identifikatori
CAS broj 125-73-5 ДаY
ATC kod none
PubChem CID 5360697
Hemijski podaci
Formula C17H23NO
Molarna masa 257.371 g/mol
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Dekstrorfan (DXO) je psihoaktivni lek iz morfinanske hemijske klase koji deluje kao antitusivni lek (supresant kašlja) i disocijativni halucinogen. On je dekstro-stereoizomer racemorfana, gde je leva-polovina levorfanol. Dekstrorfan se proizvodi O-demetilacijom dekstrometorfana CYP2D6-om. Dekstrorfan je NMDA antagonist i doprinosi riziku zloupotrebe dekstrometorfana.[1]

Farmakologija[уреди]

Literatura[уреди]

  1. Zawertailo, LA; Kaplan, HL; Busto, UE; Tyndale, RF; Sellers, EM (1998). „Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study”. Journal of clinical psychopharmacology. 18 (4): 332—7. PMID 9690700. 
  2. Wong BY, Coulter DA, Choi DW, Prince DA (1988). „Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices”. Neuroscience Letters. 85 (2): 261—6. doi:10.1016/0304-3940(88)90362-X. PMID 2897648. 
  3. Church J, Jones MG, Davies SN, Lodge D (1989). „Antitussive agents as N-methylaspartate antagonists: further studies”. Canadian Journal of Physiology and Pharmacology. 67 (6): 561—7. PMID 2673498. 
  4. 4,0 4,1 Kamel IR, Wendling WW, Chen D, Wendling KS, Harakal C, Carlsson C (2008). „N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries”. Journal of Neurosurgical Anesthesiology. 20 (4): 241—8. doi:10.1097/ANA.0b013e31817f523f. PMID 18812887. 
  5. Richter A, Löscher W (1997). „Dextrorphan, but not dextromethorphan, exerts weak antidystonic effects in mutant dystonic hamsters”. Brain Research. 745 (1-2): 336—8. doi:10.1016/S0006-8993(96)01254-1. PMID 9037429. 
  6. Chou YC, Liao JF, Chang WY, Lin MF, Chen CF (1999). „Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan”. Brain Research. 821 (2): 516—9. doi:10.1016/S0006-8993(99)01125-7. PMID 10064839. 
  7. Damaj MI, Flood P, Ho KK, May EL, Martin BR (2005). „Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity”. The Journal of Pharmacology and Experimental Therapeutics. 312 (2): 780—5. doi:10.1124/jpet.104.075093. PMID 15356218. 
  8. Hernandez SC, Bertolino M, Xiao Y, Pringle KE, Caruso FS, Kellar KJ (2000). „Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors”. J. Pharmacol. Exp. Ther. 293 (3): 962—7. PMID 10869398. 
  9. Kim HC; Ko KH; Kim WK; et al. (2001). „Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan”. Behavioural Brain Research. 120 (2): 169—75. doi:10.1016/S0166-4328(00)00372-7. PMID 11182165. 

Spoljašnje veze[уреди]

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