Escitalopram

Escitalopram
IUPAC ime
	(S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
Klinički podaci
Kategorija trudnoće	C;
Način primene	Oralno
Pravni status
Pravni status	Rx Only (U.S) POM (U.K);
Farmakokinetički podaci
Bioraspoloživost	80%
Vezivanje proteina	~56%
Metabolizam	Jetra, posebno enzimi CYP3A4 i CYP2C19
Poluvreme eliminacije	27–32 časa
Identifikatori
CAS broj	128196-01-0
ATC kod	N06AB10 (WHO)
PubChem	CID 146570
DrugBank	APRD00683
ChemSpider	129277
UNII	4O4S742ANY
ChEMBL	CHEMBL1508
Hemijski podaci
Formula	C20H21FN2O
Molarna masa	324.392 g/mol; (414.43 kao oksalat)
	SMILES Fc1ccc(cc1)[C@@]3(OCc2cc(C#N)ccc23)CCCN(C)C; ;
	InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1 ; Key:WSEQXVZVJXJVFP-FQEVSTJZSA-N ;

Escitalopram (Leksapro, Cipraleks, Seropleks, Leksamil, Leksam, Elicea) je antidepresiv iz klase selektivnih inhibitora preuzimanja serotonina (SSRI). On je odobren od strane FDA za lečenje odraslih osoba sa kliničkom depresijom.^[1] i generalizovanim anksioznim poremećajem^[2]

Escitalopram je S-stereoizomer (enantiomer) ranijeg Lundbeckovog leka citaloprama, odakle potiče ime escitalopram. Escitalopram je poznat po svojoj visokoj selektivnosti za inhibiciju preuzimanja serotonina. On poseduje tipične nuspojave SSRI klase: mučninu, probleme sa spavanjem, seksualne probleme i generalni umor..

Reference

^ Kennedy SH, Andersen HF, Thase ME (2009). „Escitalopram in the treatment of major depressive disorder: a meta-analysis”. Current Medical Research and Opinion. 25 (1): 161—75. PMID 19210149. doi:10.1185/03007990802622726.
^ Lenze EJ, Rollman BL, Shear MK, Dew MA, Pollock BG, Ciliberti C, Costantino M, Snyder S, Shi P, Spitznagel E, Andreescu C, Butters MA, Reynolds CF (2009). „Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial”. JAMA : the Journal of the American Medical Association. 301 (3): 295—303. PMC 2840403 . PMID 19155456. doi:10.1001/jama.2008.977.

Literatura

Royal Pharmaceutical Society of Great Britain (2009). British National Formulary (BNF 58). UK: BMJ Group and RPS Publishing. ISBN 9780853697787.
Royal Geographical Society (2008). British National Formulary: September 2008 (British National Formulary). London: Pharmaceutical Press. ISBN 978-0-85369-778-7.

Spoljašnje veze

Mediji vezani za članak Escitalopram na Vikimedijinoj ostavi

[pmid19210149-1] Kennedy SH, Andersen HF, Thase ME (2009). „Escitalopram in the treatment of major depressive disorder: a meta-analysis”. Current Medical Research and Opinion. 25 (1): 161—75. PMID 19210149. doi:10.1185/03007990802622726.

[pmid19155456-2] Lenze EJ, Rollman BL, Shear MK, Dew MA, Pollock BG, Ciliberti C, Costantino M, Snyder S, Shi P, Spitznagel E, Andreescu C, Butters MA, Reynolds CF (2009). „Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial”. JAMA : the Journal of the American Medical Association. 301 (3): 295—303. PMC 2840403 . PMID 19155456. doi:10.1001/jama.2008.977.

[1]

[2]

p r u Modulatori sigma receptora
σ₁	Agonisti: 3-PPP 4-PPBP 5-MeO-DMT Alazocin (SKF-10047) Amantadin ANAVEX2-73 Arketamin BD-737 BD-1052 Kaptodiam Citalopram CGRP Kloperastin Kokain Kutamezin (SA-4503) Ciklazocin Dehidroepiandrosteron (DHEA) (prasteron) Dehidroepiandrosteron sulfat (DHEA-S) (prasteron sulfat) Dekstralorfan Dekstrometorfan (DXM) Dekstrorfan (DXO) Dimemorfan Dimetiltriptamin (DMT) Ditolilgvanidin (DTG) Donepezil Eliprodil Escitalopram Fabomotizol (afobazol) Fluoksetin Fluvoksamin Ifenprodil Igmesin (JO-1784) IPAB Ketamin L-687384 MDMA (midomafetamin) Memantin Metamfetamin Metoksetamin Metilfenidat Nepinalon Neuropeptid Y Noskapin OPC-14523 Opipramol Pentazocin Pentoksiverin (karbetapentan) PRE-084 Pregnenolon Pregnenolon sulfat Pridopidin Racemetorfan (metorfan) Racemorfan (morfanol) UMB-23 UMB-82 Antagonisti: 3-PPP AC-927 BD-1008 BD-1031 BD-1047 BD-1060 BD-1063 BD-1067 BMY-14802 (BMS-181100) CM-156 Dup-734 E-5842 E-52862 (S1RA) Haloperidol LR-132 LR-172 MS-377 NE-100 NPC-16377 Panamesin (EMD-57455) PD-144418 Pentazocin Progesteron Rimkazol (BW-234U) Sertralin SR-31742A Alosterni modulatori: Fenitoin; Pozitivni: Metilfenilpiracetam SOMCL-668 Nepoznati/nerazvrstani: 3-Metoksidekstralorfan 3-MeO-PCP 4C-T-2 4-IBP 4-IPBS 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Amitriptilin Azidopamil Hlorpromazin Klemastin Klomipramin Klorgilin D-Deprenil DiPT DPT Ibogain Imipramin KCR-12-83.1 Nemonaprid Noribogain RHL-033 RS-67,333 RTI-55 Šafran Safinamid Selegilin Spipetijan Trifluoperazin W-18 YKP10A
σ₂	Agonisti: 3-PPP Arketamin BD-1047 BD1063 Ditolilgvanidin (DTG) DKR-1005 DKR-1051 Haloperidol Ifenprodil Ketamin MDMA (midomafetamin) Metamfetamin OPC-14523 Opipramol PB-28 Fenciklidin Siramesin (Lu 28-179) UKH-1114 Antagonisti: AC-927 BD-1008 BD-1067 CM-156 CT-1812 LR-172 MIN-101 Panamesin (EMD-57455) SAS-0132 Nepoznati/nerazvrstani: 3-Metoksidekstralorfan 3-MeO-PCE 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Klemastin DiPT DPT Ibogain Nemonaprid Nepinalon Noribogain Pentazocin RS-67,333 Safinamid TMA UMB-23 UMB-82 W-18
Neraz- vrstani	Agonisti: Berberin Etilketazocin Forfit Metafit Nalbufin Naluzotan Tapentadol Tenociklidin Antagonisti: AHD1 AZ66 Lamotrigin Nalokson SM-21 UMB-100 UMB-101 UMB-103 UMB-116 YZ-011 YZ-069 YZ-185 Alosterni modulatori: SKF-83959 Nepoznati/nerazvrstani: 18-Metoksikoronaridin BMY-13980 Butaklamol Karamifen Karvotrolin Hlorfenamin (hlorfeniramin) Hlorpromazin Cinarizin Cinuperon Klocapramin Dezocin EMD-59983 Hipericin (kantarion) Flufenazin Gevotrolin (WY-47384) Mepiramin (pirilamin) Molindon Perfenazin Pimozid Proadifen Prometazin Propranolol Hinidin Remoksiprid SL 82.0715 SR-31747A Tiospiron (BMY-13859) Venlafaksin