SB-357,134 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan, selektivan i oralno aktivan antagonist5-HT6receptora.[1] SB-357,134 i drugi 5-HT6 antagonisti manifestuju nootropne efekte u životinjskim studijama,[2][3][4] i potencijalno mogu da služe kao treatmen za kognitivne poremećaje kao što su šizofrenija i Alchajmerova bolest.
^Rogers, DC; Hagan, JJ (2001). „5-HT6 receptor antagonists enhance retention of a water maze task in the rat”. Psychopharmacology. 158 (2): 114—9. PMID11702084. doi:10.1007/s002130100840.
^Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT; Smith, DR (2002). „Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist”. Pharmacology, Biochemistry, and Behavior. 71 (4): 645—54. PMID11888556. doi:10.1016/S0091-3057(01)00742-0.
^Perez-García, G; Meneses, A (2005). „Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task”. Pharmacology, Biochemistry, and Behavior. 81 (3): 673—82. PMID15964617. doi:10.1016/j.pbb.2005.05.005.