5-Metoksitriptamin

Из Википедије, слободне енциклопедије
5-Metoksitriptamin
(IUPAC) ime
2-(5-Methoxy-1H-indol-3-yl)ethanamine
Klinički podaci
Identifikatori
CAS broj 608-07-1
ATC kod  ?
PubChem[1][2] 1833
ChemSpider[3] 1767
KEGG[4] C05659 YesY
ChEMBL[5] CHEMBL8165 YesY
Hemijski podaci
Formula C11H14N2O 
Mol. masa 190.242 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

5-Metoksitriptamin (5-MT, meksamin) je derivat triptamina. On je blisko srodan neurotransmiterima serotoninu i melatoninu. Za 5-MT je pokazano da se prirodno javlja u telu u niskim nivoima.[6] On je proizvod dekarboksilacije melatonina u epifizi.[6]

5-MT deluje kao pun agonist 5-HT1, 5-HT2, 5-HT4, 5-HT6, i 5-HT7 receptora.[7][8][9][10][11][12][13] On nema afinitet za 5-HT3 receptor. Njegov afinitet za 5-HT1E receptor je veoma slab u poređenju sa drugim 5-HT1 receptorima.[10][14]

Vidi još[уреди]

Референце[уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining“. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG“. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. 6,0 6,1 Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ. (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).“. J Endocrinol. 118 (3): 389–397. DOI:10.1677/joe.0.1180389. PMID 2460575. 
  7. Wu PH, Gurevich N, Carlen PL. (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.“. Neurosci Lett. 86 (1): 72–76. DOI:10.1016/0304-3940(88)90185-1. PMID 2966313. 
  8. Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K. (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.“. Eur J Pharmacol. 323 (2-3): 235–240. DOI:10.1016/S0014-2999(97)00029-0. PMID 9128844. 
  9. Amemiya N, Hatta S, Takemura H, Ohshika H. (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.“. Eur J Pharmacol. 318 (2-3): 403–409. DOI:10.1016/S0014-2999(96)00777-7. PMID 9016931. 
  10. 10,0 10,1 Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE. (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.“. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9–16. PMID 2402303. 
  11. Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ. (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.“. Neuropharmacology. 36 (4-5): 713–720. DOI:10.1016/S0028-3908(97)00019-1. PMID 9225298. 
  12. Hemedah M, Coupar IM, Mitchelson FJ. (1999). „[3H-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.“]. Br J Pharmacol. 126 (1): 179–188. DOI:10.1038/sj.bjp.0702293. PMC 1565797. PMID 10051134. 
  13. Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000.). „Serotonin Receptor Subtypes and Ligands“. American College of Neurophyscopharmacology Приступљено 11. 4. 2008.. 
  14. Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2, 9781588295682. 

Литература[уреди]