Kotinin

Из Википедије, слободне енциклопедије
Kotinin
Cotinine Structural Formulae.png
IUPAC ime
(5S)-1-metil-5-(3-piridil)pirolidin-2-on
Klinički podaci
Način primene Oralno, pušenjem
Pravni status
Pravni status
  • ℞ (Prescription only)
Farmakokinetički podaci
Poluvreme eliminacije 20 sata
Identifikatori
CAS broj 486-56-6 ДаY
ATC kod none
PubChem CID 854019
ChemSpider 746405 ДаY
UNII K5161X06LL ДаY
ChEMBL CHEMBL578211 ДаY
Hemijski podaci
Formula C10H12N2O
Molarna masa 176,22 g/mol
  (verify)

Kotinin je alkaloid prisutan u duvanu i kao metabolit nikotina.[1][2] Reč "kotinin" je anagram "nikotina". Kotinin se koristi kao biomarker za izlaganje duvanskom dimu. On je u prodaji kao antidepresiv pod imenom Scotine.[1]

Slično nikotinu, kotinin se vezuje za, aktivira, i desenzituje neuronski nikotinske acetilholinske receptore, mada sa znatno nižom potentnošću.[2][3][4][5] On ispoljava nootropne i antipsihoticima slične efekte.[6][7]

Reference[уреди]

  1. 1,0 1,1 Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. 2,0 2,1 Dwoskin LP, Teng L, Buxton ST, Crooks PA (1999). „(S)-(-)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H]dopamine release from rat striatal slices in a calcium-dependent manner”. The Journal of Pharmacology and Experimental Therapeutics. 288 (3): 905—11. PMID 10027825. 
  3. Anderson DJ, Arneric SP (1994). „Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain”. European Journal of Pharmacology. 253 (3): 261—7. doi:10.1016/0014-2999(94)90200-3. PMID 8200419. 
  4. Briggs CA, McKenna DG (1998). „Activation and inhibition of the human alpha7 nicotinic acetylcholine receptor by agonists”. Neuropharmacology. 37 (9): 1095—102. doi:10.1016/S0028-3908(98)00110-5. PMID 9833639. 
  5. Buccafusco JJ, Shuster LC, Terry AV (2007). „Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine”. Neuroscience Letters. 413 (1): 68—71. doi:10.1016/j.neulet.2006.11.028. PMID 17157984. 
  6. Buccafusco JJ, Terry AV (2009). „A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists”. Biochemical Pharmacology. 78 (7): 852—62. doi:10.1016/j.bcp.2009.06.102. PMID 19577545. 
  7. Buccafusco JJ, Beach JW, Terry AV (2009). „Desensitization of nicotinic acetylcholine receptors as a strategy for drug development”. The Journal of Pharmacology and Experimental Therapeutics. 328 (2): 364—70. doi:10.1124/jpet.108.145292. PMC 2682277Слободан приступ. PMID 19023041. 

Literatura[уреди]

Spoljašnje veze[уреди]