Lentinan

Из Википедије, слободне енциклопедије
Lentinan
Lentinan.svg
IUPAC ime
β-D-glukopiranozil-(1→6)-[β-D-glukopiranozil-(1→3)-[β-D-glukopiranozil-(1→6)]-β-D-glukopiranozil-(1→3)-β-D-glukopiranozil-(1→3)β-D-glukopiranozil-(1→3)]-β-D-glukopiranoza
Klinički podaci
Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 37339-90-5 ДаY
ATC kod L03AX01 (WHO)
PubChem CID 37723
KEGG D01695 ДаY
Sinonimi (2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-3,5-dihidroksi-2-(hidroksimetil)-6-[(2R,3R,4S,5R,6R)-2,3,5-trihidroksi-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihidroksi-6-(hidroksimetil)oksan-2-il]oksimetil]oksan-4-il]oksioksan-4-il]oksi-3,5-dihidroksi-6-(hidroksimetil)oksan-4-il]oksi-3,5-dihidroksi-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihidroksi-6-(hidroksimetil)oksan-2-il]oksimetil]oksan-4-il]oksi-6-(hidroksimetil)oksan-3,4,5-triol
Hemijski podaci
Formula C42H72O36
Molarna masa 1152.99948 g/mol
  (verify)

Lentinan je beta-glukan sa glikozidnim β-1,3:β-1,6 vezama.[1] On je antitumorni polisaharid iz šitake (Lentinula edodes) pečurke.[1] Lentinan je polisaharid sa molekulskom težinom od oko 500.000 Da. Japanska farmaceutska kompanija Ajinomoto je razvila lek Lentinan, koji se intravenozno dozira kao agens protiv kancera.[2]

Lentinan je jedan od lekova protiv kancera[3] za koji je pokazano da utiče na odbrambeni imunski sistem domaćina.[4]

Klinička israživanja na obolelima od raka su ukazala na vezu između lentinana i povišenog stepena perživljavanja, poboljšanog kvaliteta života, i umanjene ponovne pojave kancera.[5][6][7][8][9][10][11][12]

Reference[уреди]

  1. 1,0 1,1 Cancer Guide Includes many abstracts
  2. „Medicinal Mushrooms:Their therapeutic properties and current medicalusage with special emphasis on cancer treatments”. 
  3. Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.”. Hepatogastroenterology. 46 (28): 2662—8. PMID 10522061. 
  4. Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group”. Hepatogastroenterology. 46 (28): 2662—8. PMID 10522061. 
  5. Yang P, Liang M, Zhang Y, Shen B. (2008). „Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC.”. Adv Ther. 25 (8): 787—94. doi:10.1007/s12325-008-0079-x. PMID 18670743. 
  6. Nimura H, Mitsumori N, Takahashi N, (2006). „[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]”. Gan to Kagaku Ryoho. 33 (1): 106—9. PMID 16897983. 
  7. Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K. (1999). „A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group.”. Hepatogastroenterology. 46 (28): 2662—8. PMID 10522061. 
  8. Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (2009). „Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer”. Anticancer Res. 29 (7): 2739—45. PMID 19596954. 
  9. Hazama S, Watanabe S, Ohashi M; et al. (2009). „Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer”. Anticancer Res. 29 (7): 2611—7. PMID 19596936. 
  10. Kataoka H, Shimura T, Mizoshita T; et al. (2009). „Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life”. Hepatogastroenterology. 56 (90): 547—50. PMID 19579640. 
  11. Isoda N, Eguchi Y, Nukaya H; et al. (2009). „Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma”. Hepatogastroenterology. 56 (90): 437—41. PMID 19579616. 
  12. Shimizu K, Watanabe S, Watanabe S; et al. (2009). „Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer”. Hepatogastroenterology. 56 (89): 240—4. PMID 19453066. 

Literatura[уреди]

Vidi još[уреди]

Spoljašnje veze[уреди]

  • Lentinan effects (antitumor and others)