1-Amino-5-fosfonoindan-1-karboksilna kiselina (APICA) je lek koji se koristi u neurološkim istraživanjima. on je selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), i bio je koristan u istraživanju te receptorske potfamilije.[1][2][3][4][5]
^Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. . Ma, Dawei; Tian, Hongqi; Sun, Hongbin; Kozikowshi, Alan P.; Pshenichkin, Sergey; Wroblewski, Jarda T. (6. 5. 1997). „Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists”. Bioorganic & Medicinal Chemistry Letters. 7 (9): 1195—1198. doi:10.1016/S0960-894X(97)00177-7.CS1 одржавање: Формат датума (веза).
^Ma, D.; Tian, H.; Zou, G. (1999). „Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors”. The Journal of Organic Chemistry. 64 (1): 120—125. PMID11674092. doi:10.1021/jo981297a.
^Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan. Xi, Zheng-Xiong; Baker, David A.; Shen, Hui; Carson, Daniel S.; Kalivas, Peter W. (2002). „Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens”. The Journal of Pharmacology and Experimental Therapeutics. 300 (1): 162—71. PMID11752112. doi:10.1124/jpet.300.1.162..
^Zhou, F.; Yao, H. H.; Wu, J. Y.; Yang, Y. J.; Ding, J. H.; Zhang, J.; Hu, G. (2006). „Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake”. Journal of Neuroscience Research. 84 (2): 268—77. PMID16752416. doi:10.1002/jnr.20897.
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