APICA (lek)

Из Википедије, слободне енциклопедије
APICA (lek)
APICA drug.png
IUPAC ime
1-Amino-5-fosfonoindan-1-karboksilna kiselina
Identifikatori
ATC kod none
ChemSpider 3881975 ДаY
ChEMBL CHEMBL277961 ДаY
Hemijski podaci
Formula C10H12NO5P
Molarna masa 257,179 g/mol
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1-Amino-5-fosfonoindan-1-karboksilna kiselina (APICA) je lek koji se koristi u neurološkim istraživanjima. on je selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), i bio je koristan u istraživanju te receptorske potfamilije.[1][2][3][4][5]

Reference[уреди]

  1. Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. doi:10.1016/S0960-894X(97)00177-7
  2. Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID 11674092
  3. Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. doi:10.1124/jpet.300.1.162 PMID 11752112
  4. Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID 12388621
  5. Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID 16752416

Spoljašnje veze[уреди]