EGLU

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EGLU
Salpha ethylglutamic acid.png
IUPAC ime
(2S)-2-amino-2-etilpentandionska kiselina
Identifikatori
ATC kod none
PubChem CID 5311079
IUPHAR/BPS 1400
Hemijski podaci
Formula C7H13NO4
Molarna masa 175,182 g/mol
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(2S)-α-Etilglutaminska kiselina (EGLU) je lek koji se koristi u neurološkim istraživanjima. On je bio jedno od prvih jedinjenja za koja je utvrđeno da deluju kao selektivni antagonisti za grupu II metabotropnih glutamatnih receptora (mGluR2/3), tako da je bio koristan u karakterizaciji i istraživanju ove receptorske familije.[1][2][3][4][5][6][7]

Reference[уреди]

  1. Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). „Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord”. Neuropharmacology 35 (8): 1029—35. doi:10.1016/S0028-3908(96)00048-2. PMID 9121605. 
  2. Huang, L; Rowan, MJ; Anwyl, R (1999). „Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro”. European Journal of Pharmacology 366 (2–3): 151—8. doi:10.1016/S0014-2999(98)00918-2. PMID 10082195. 
  3. Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). „Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception”. Neuropharmacology 40 (3): 319—26. doi:10.1016/S0028-3908(00)00160-X. PMID 11166324. 
  4. Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). „Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat”. Brain Research 1027 (1–2): 151—60. doi:10.1016/j.brainres.2004.08.052. PMID 15494166. 
  5. Cahusac, PM; Wan, H (2007). „Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo”. Neuroscience 146 (1): 202—12. doi:10.1016/j.neuroscience.2007.01.049. PMID 17346894. 
  6. Kim, WY; Vezina, P; Kim, JH (2008). „Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment”. Behavioural Brain Research 191 (1): 62—6. doi:10.1016/j.bbr.2008.03.010. PMID 18433894. 
  7. Altinbilek, B; Manahan-Vaughan, D (2009). „A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory”. Neuroscience 158 (1): 149—58. doi:10.1016/j.neuroscience.2008.07.045. PMID 18722513. 

Spoljašnje veze[уреди]