CBiPES
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 856702-40-4  |
| ATC kod | none |
| PubChem | CID 9864510 |
| ChemSpider | 8040202 |
| Hemijski podaci | |
| Formula | C21H19N3O2S |
| Molarna masa | 377,459 |
| |
| |
CBiPES je lek koji se koristi u naučnim istraživanjima koji deluje kao selektivni pozitivni alosterični modulator za metabotropni glutamat receptor grupe II podtip mGluR2. On ima potencijalno antipsihotične efekte na životinjskim modelima i koristi se za istraživanje uloge mGluR2 receptora u šizofreniji i srodnim poremećajima.[1][2][3]
Osobine
[уреди | уреди извор]CBiPES je organsko jedinjenje, koje sadrži 21 atom ugljenika i ima molekulsku masu od 377,459 Da.
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 4 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 6 |
| Particioni koeficijent[4] (ALogP) | 3,1 |
| Rastvorljivost[5] (logS, log(mol/L)) | -6,0 |
| Polarna površina[6] (PSA, Å2) | 82,4 |
Reference
[уреди | уреди извор]- ^ Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, et al. (април 2005). . „Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)”. Psychopharmacology. 179 (1): 271—83. PMID 15717213. S2CID 2699540. doi:10.1007/s00213-004-2099-9.
- ^ Fell MJ, Katner JS, Johnson BG, Khilevich A, Schkeryantz JM, Perry KW, Svensson KA (март 2010). . „Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge”. Neuropharmacology. 58 (3): 632—9. PMID 19951716. S2CID 7262560. doi:10.1016/j.neuropharm.2009.11.014.
- ^ Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, et al. (март 2013). . „Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR”. Neuropharmacology. 66: 264—73. PMID 22659090. S2CID 42448364. doi:10.1016/j.neuropharm.2012.05.023.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
