Fenobam

Из Википедије, слободне енциклопедије
Fenobam
Fenobam.svg
Nazivi
IUPAC naziv
1-(3-hlorofenil)-3-(3-metil-5-okso-4H-imidazol-2-il)ureja
Identifikacija
3D model (Jmol)
ECHA InfoCard 100.165.052
MeSH fenobam
Svojstva
C11H11ClN4O2
Molarna masa 266,684
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

Fenobam je imidazolni derivat razvijen tokom kasnih 1970-tih kao anksiolitski lek sa svojevremeno nepoznatim molekulskim ciljem u mozgu. Naknadno, je utvrđeno da fenobam deluje potentan i selektivan negativni alosterni modulator metabotropnog glutamatnog receptora mGluR5.[1][2] On je korišten kao vodeće jedinjenje za razvoj niza novijih mGluR5 antagonista.[3][4][5][6]

Hemija[уреди]

Fenobam se može pripremiti u dva koraka iz kreatina.[7]

Fenobam.png

Reference[уреди]

  1. Porter RH; Jaeschke G; Spooren W; et al. (2005). „Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity”. J. Pharmacol. Exp. Ther. 315 (2): 711—21. doi:10.1124/jpet.105.089839. PMID 16040814. 
  2. Marino, MJ; Conn, PJ (2006). „Glutamate-based therapeutic approaches: Allosteric modulators of metabotropic glutamate receptors”. Current opinion in pharmacology. 6 (1): 98—102. doi:10.1016/j.coph.2005.09.006. PMID 16368268. 
  3. Wållberg, A; Nilsson, K; Osterlund, K; Peterson, A; Elg, S; Raboisson, P; Bauer, U; Hammerland, LG; et al. (2006). „Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues”. Bioorganic & medicinal chemistry letters. 16 (5): 1142—5. doi:10.1016/j.bmcl.2005.11.092. PMID 16380255. 
  4. Ceccarelli, SM; Jaeschke, G; Buettelmann, B; Huwyler, J; Kolczewski, S; Peters, JU; Prinssen, E; Porter, R; et al. (2007). „Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure”. Bioorganic & medicinal chemistry letters. 17 (5): 1302—6. doi:10.1016/j.bmcl.2006.12.006. PMID 17189691. 
  5. Jaeschke, G; Porter, R; Büttelmann, B; Ceccarelli, SM; Guba, W; Kuhn, B; Kolczewski, S; Huwyler, J; et al. (2007). „Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists”. Bioorganic & medicinal chemistry letters. 17 (5): 1307—11. doi:10.1016/j.bmcl.2006.12.033. PMID 17196387. 
  6. Gichinga, Moses G.; Olson, Jeremy P.; Butala, Elizabeth; Navarro, Hernán A.; Gilmour, Brian P.; Mascarella, S. Wayne; Carroll, F. Ivy (2011). „Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam”. ACS Medicinal Chemistry Letters. 2 (12): 882—884. doi:10.1021/ml200162f. PMC 3328804Слободан приступ. PMID 22523618. 
  7. Rasmussen, C. R.; 1976, U.S. Patent 3.983.135.

Spoljašnje veze[уреди]