Perampanel
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 105 h |
| Identifikatori | |
| CAS broj | 380917-97-5  |
| ATC kod | N03AX22 (WHO) |
| PubChem | CID 9924495 |
| DrugBank | DB08883 |
| ChemSpider | 8100130 |
| ChEBI | CHEBI:71013 |
| ChEMBL | CHEMBL1214124 |
| Hemijski podaci | |
| Formula | C23H15N3O |
| Molarna masa | 349.384 |
| |
| |
Perampanel (INN/USAN, prodajno ime Fycompa) antiepileptički je lek koji deluje kao selektivni nekompetitivni antagonist AMPA receptora, jednog od glavnih tipova jonotropnih glutamatnih receptora.[1][2][3][4][5]
Reference
[уреди | уреди извор]- ^ Rogawski, M. A. (2011). „Revisiting AMPA Receptors as an Antiepileptic Drug Target”. Epilepsy Currents. 11 (2): 56—63. PMC 3117497
. PMID 21686307. doi:10.5698/1535-7511-11.2.56.
- ^ Rogawski MA, Hanada T. (2013). „Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist”. Acta Neurol Scand. 127 (Suppl. 197): 19—24. PMC 4506647 . PMID 23480152. doi:10.1111/ane.12100.
- ^ Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. Hanada, T.; Hashizume, Y.; Tokuhara, N.; Takenaka, O.; Kohmura, N.; Ogasawara, A.; Hatakeyama, S.; Ohgoh, M.; Ueno, M.; Nishizawa, Y. (2011 Jul). „Perampanel: A novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy”. Epilepsia. 52 (7): 1331—40. PMID 21635236. doi:10.1111/j.1528-1167.2011.03109.x. Проверите вредност парамет(а)ра за датум:
|date=(помоћ).. Epub 2011 Jun 2. - ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор] | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
