SIB-1893

Из Википедије, слободне енциклопедије
SIB-1893
SIB-1893 structure.png
IUPAC ime
(E)-2-metil-6-(2-feniletenil)piridin
Identifikatori
CAS broj 6266-99-5 ДаY
ATC kod none
PubChem CID 235382
ChEMBL CHEMBL88612 ДаY
Hemijski podaci
Formula C14H13N
Molarna masa 195,259 g/mol
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SIB-1893 je lek koji se koristi u naučnim istraživanjima. On je bio jedan od prvih jedinjenja razvijenih kao selektivni antagonisti za metabotropni glutamatni receptor podtip mGluR5.[1] On ima antikonvulsivno i neuroprotektivno dejstvo,[2] i redukuje otpuštanje glutamata.[3] On takođe deluje kao pozitivni alosterni modulator mGluR4 receptora.[4]

Reference[уреди]

  1. Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC (1999). „SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5”. The Journal of Pharmacology and Experimental Therapeutics 290 (1): 170—81. PMID 10381773. 
  2. Chapman AG, Nanan K, Williams M, Meldrum BS (2000). „Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)”. Neuropharmacology 39 (9): 1567—74. doi:10.1016/S0028-3908(99)00242-7. PMID 10854901. 
  3. Wang SJ, Sihra TS (2004). „Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes)”. The Journal of Pharmacology and Experimental Therapeutics 309 (3): 951—8. doi:10.1124/jpet.103.064881. PMID 14982967. 
  4. Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT (2003). „Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP”. British Journal of Pharmacology 138 (6): 1026—30. doi:10.1038/sj.bjp.0705159. PMC 1573757. PMID 12684257. 

Spoljašnje veze[уреди]