LY-487,379

Из Википедије, слободне енциклопедије
LY-487,379
LY-487,379 structure.png
IUPAC ime
N-(4-(2-metoksifenoksi)fenil)- N-(2,2,2-trifluoroetilsulfonil)pirid- 3-ilmetilamin
Identifikatori
ATC kod none
PubChem CID 9825084
IUPHAR/BPS 1402
ChEMBL CHEMBL108939 ДаY
Hemijski podaci
Formula C21H19F3N2O4S
Molarna masa 452,446 g/mol
  (verify)

LY-487,379 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni pozitivni alosterni modulator za metabotropni glutamatni receptor grupe II mGluR2.[1] On se koristio za studiranje strukture i funkcije ovog tipa receptor,[2][3] i LY-487,379 se zajedno sa drugim mGluR2/3 agonistima i pozitivnim modulatorima istražuje kao mogući antipsihotik i anksiolitik.[4][5][6][7]

Reference[уреди]

  1. {{Cite journal| author = Johnson, M. P.; Baez, M.; Jagdmann Jr, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A. et al. | title = Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine | journal = Journal of Medicinal Chemistry | volume = 46 | pages = 3189–3192 | year = 2003 | doi = 10.1021/jm034015u| pmid = 12852748| issue = 15}
  2. HSchaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G.; et al. (2003). „Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2”. Molecular Pharmacology. 64 (4): 798—810. doi:10.1124/mol.64.4.798. PMID 14500736. 
  3. Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). „Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus”. Neuropharmacology. 49: 57—50. doi:10.1016/j.neuropharm.2005.03.006. PMID 15993439. 
  4. Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). „A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity”. Journal of Pharmacology and Experimental Therapeutics. 315 (3): 1181—7. doi:10.1124/jpet.105.091074. PMID 16123306. 
  5. {{Cite journal | author = Marino| first2 = P. | title = Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors | journal = Current Opinion in Pharmacology | volume = 6 | issue = 1 | pages = 98–102 | year = 2006 | pmid = 16368268 | doi = 10.1016/j.coph.2005.09.006 | last2 = Conn }
  6. Harich; Gross, G.; Bespalov, A. (2007). „Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment”. Psychopharmacology. 192 (4): 511—519. doi:10.1007/s00213-007-0742-y. PMID 17318501. 
  7. Dillon Ripley (1958). „Extinct and Vanishing Birds of the World”. The Auk. 75 (4): 480—482. JSTOR 4082117. PMID 190790739 . 

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