LY-487,379

Из Википедије, слободне енциклопедије
LY-487,379
(IUPAC) ime
N-(4-(2-metoksifenoksi)fenil)- N-(2,2,2-trifluoroetilsulfonil)pirid- 3-ilmetilamin
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 9825084
ChEMBL[3] CHEMBL108939 YesY
Hemijski podaci
Formula C21H19F3N2O4S 
Mol. masa 452,446 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

LY-487,379 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni pozitivni alosterni modulator za metabotropni glutamatni receptor grupe II mGluR2.[4] On se koristio za studiranje strukture i funkcije ovog tipa receptor,[5][6] i LY-487,379 se zajedno sa drugim mGluR2/3 agonistima i pozitivnim modulatorima istražuje kao mogući antipsihotik i anksiolitik.[7][8][9][10]

Reference[уреди]

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.“. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ^ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities“. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ^ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery“. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ^ {{Cite journal| author = Johnson, M. P.; Baez, M.; Jagdmann Jr, G. E.; Britton, T. C.; Large, T. H.; Callagaro, D. O.; Tizzano, J. P.; Monn, J. A. et al. | title = Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity ofN-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine | journal = Journal of Medicinal Chemistry | volume = 46 | pages = 3189–3192 | year = 2003 | doi = 10.1021/jm034015u| pmid = 12852748| issue = 15}
  5. ^ HSchaffhauser, H.; Rowe, B. A.; Morales, S.; Chavez-noriega, L. E.; Yin, R.; Jachec, C.; Rao, S. P.; Bain, G. et al. (2003). „Pharmacological Characterization and Identification of Amino Acids Involved in the Positive Modulation of Metabotropic Glutamate Receptor Subtype 2“. Molecular Pharmacology 64 (4): 798–810. DOI:10.1124/mol.64.4.798. PMID 14500736. 
  6. ^ Poisik, O.; Raju, D. V.; Verreault, M.; Rodriguez, A.; Abeniyi, O. A.; Conn, P. J.; Smith, Y. (2005). „Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus“. Neuropharmacology 49: 57–50. DOI:10.1016/j.neuropharm.2005.03.006. PMID 15993439. 
  7. ^ Galici, R.; Echemendia, N. G.; Rodriguez, A. L.; Conn, P. J. (2005). „A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity“. Journal of Pharmacology and Experimental Therapeutics 315 (3): 1181–7. DOI:10.1124/jpet.105.091074. PMID 16123306. 
  8. ^ {{Cite journal | author = Marino| first2 = P. | title = Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors | journal = Current Opinion in Pharmacology | volume = 6 | issue = 1 | pages = 98–102 | year = 2006 | pmid = 16368268 | doi = 10.1016/j.coph.2005.09.006 | last2 = Conn }
  9. ^ Harich; Gross, G.; Bespalov, A. (2007). „Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment“. Psychopharmacology 192 (4): 511–519. DOI:10.1007/s00213-007-0742-y. PMID 17318501. 
  10. ^ Dillon Ripley (1958). „Extinct and Vanishing Birds of the World“. The Auk 75 (4): 480–482. JSTOR 4082117. PMID 190790739. 

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