PCCG-4

Из Википедије, слободне енциклопедије
PCCG-4
PCCG-4 structure.png
IUPAC ime
(2S,1'S,2'S,3'R)-2-(2'karboksi-3'-fenilciklopropil)glicin
Identifikatori
ATC kod none
PubChem CID 5311344
ChemSpider 4470843 ДаY
ChEMBL CHEMBL39573 ДаY
Hemijski podaci
Formula C12H13NO4
Molarna masa 235,235 g/mol
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PCCG-4 je istraživački lek koji deluje kao selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), sa neznatnom selektivnošću za mGluR2. Ona nije dovoljna za razlikovanje mGluR2 i mGluR3 responsa. PCCG-4 se koristi u istraživanjima funkcije grupe II metabotropnih glutamatnih receptora.[1][2][3][4][5]

Reference[уреди]

  1. Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (1996). „Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist”. Journal of Medicinal Chemistry 39 (11): 2259—69. doi:10.1021/jm960059+. PMID 8667369. 
  2. Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (1996). „(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors”. Molecular Pharmacology 50 (1): 6—9. PMID 8700119. 
  3. Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (1997). „Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist”. The European Journal of Neuroscience 9 (7): 1350—5. PMID 9240392. 
  4. Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (1999). „Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes”. Glia 27 (3): 275—81. PMID 10457374. 
  5. Vetter P, Garthwaite J, Batchelor AM (1999). „Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors”. Neuropharmacology 38 (6): 805—15. doi:10.1016/S0028-3908(99)00003-9. PMID 10465684. 

Spoljašnje veze[уреди]