Fenoksipropazin

Из Википедије, слободне енциклопедије

{{Drugbox-lat | IUPAC_name = (1-metil-2-fenoksi-etil)hidrazin | image = Phenoxypropazine skeletal.svg | width = 200px | image2 = | width2 =

| tradename = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oralno

| bioavailability = | metabolism = | elimination_half-life = | excretion =

| CAS_number_Ref =  ДаY | CAS_number = 3818-37-9 | ATC_prefix = none | ATC_suffix = | PubChem = 71467 | IUPHAR_ligand = | ChEMBL_Ref = | ChemSpiderID = 64548 | ChEMBL = 1909286 | DrugBank_Ref = | DrugBank = | UNII = 8E92V52324

| C=9 | H=14 | N=2 | O=1 | molecular_weight = 166,22 -{g/mol} | smiles = | StdInChI_Ref =  ДаY | StdInChI = | StdInChIKey_Ref =  ДаY | StdInChIKey = }} Fenoksipropazin (prodajno ime Drazin) je ireverzibilni i neselektivni inhibitor monoaminoksidaze (MAOI) iz hidrazinske hemijske klase. On je uveden u upotrebu kao antidepresiv 1961, ali je naknadno povućen sa tržišta 1966. zbog moguće pojave hepatotoksičnosti.[1][2][3][4][5]

Vidi još[уреди]

Reference[уреди]

  1. LEAHY MR, ROSE JT, PLOWMAN R (1963). „A preliminary study of phenoxypropazine in the treatment of depression”. The American Journal of Psychiatry. 119: 986—7. PMID 13928824. 
  2. IMLAH NW (1963). „Preliminary report on phenoxypropazine”. The American Journal of Psychiatry. 119: 1091—2. PMID 13956423. 
  3. ROSE JT, LEAHY MR, PLOWMAN R (1963). „A comparison of phenoxypropazine and amitriptyline in depression”. The American Journal of Psychiatry. 120: 393—5. PMID 14069469. 
  4. ROSE JT (1964). „Phenoxypropazine and chlordiazepoxide in depression”. The American Journal of Psychiatry. 120: 899—900. PMID 14129290. 
  5. MCWHINNEY IR, MORRELL DC (1965). „Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice”. The Journal of the College of General Practitioners. 9: 95—9. PMC 1878242Слободан приступ. PMID 14254271. 

Spoljašnje veze[уреди]