GNRHR2

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Gonadotropin-oslobađajući hormonski receptor II
Identifikatori
Simboli GNRHR2; GnRH-II-R
Vanjski ID IUPHAR: GnRH2 GeneCards: GNRHR2 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 114814 n/a
Ensembl ENSG00000211451 n/a
UniProt Q96P88 n/a
RefSeq (mRNA) NR_002328 n/a
RefSeq (protein) n/a n/a
Lokacija (UCSC) Chr 1:
145.51 - 145.52 Mb
n/a
PubMed pretraga [1] n/a

GNRHR2, gonadotropin-oslobađajući hormonski receptor II, je protein koji je kod ljudi kodiran GNRHR2 genom.[1][2]

Receptor gonadotropin oslobađajućeg hormona 2 (GnRH2) je G protein spregnuti receptor, koji je kodiran GnRHR2 genom kod ne-hominoidnih primata i ne-sisarskih kičmenjaka. Kod ljudi, N-terminus protein ima pomeranje okvira čitanja sekvence i prerani stop kodon. Mada dolazi do transkripcije, još uvek nije potpuno razjašnjeno da li je receptor funkcionalan. Alternativne splajsne varijante su poznate. Nentranskribovani GnRHR2 pseudogen takođe postoji na hromozomu 14.[2]

Vidi još[уреди]

Literatura[уреди]

  1. ^ Faurholm B, Millar RP, Katz AA (2001). „The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci”. Genomics. 78 (1–2): 15—8. PMID 11707068. doi:10.1006/geno.2001.6650. 
  2. 2,0 2,1 „Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2”. 

Dodatna literatura[уреди]

  • Neill JD (2002). „GnRH and GnRH receptor genes in the human genome”. Endocrinology. 143 (3): 737—43. PMID 11861490. doi:10.1210/en.143.3.737. 
  • Millar R; Conklin D; Lofton-Day C; et al. (1999). „A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript”. J. Endocrinol. 162 (1): 117—26. PMID 10396028. doi:10.1677/joe.0.1620117. 
  • Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). „A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates”. Biochem. Biophys. Res. Commun. 282 (4): 1012—8. PMID 11352653. doi:10.1006/bbrc.2001.4678. 
  • van Biljon W; Wykes S; Scherer S; et al. (2003). „Type II gonadotropin-releasing hormone receptor transcripts in human sperm”. Biol. Reprod. 67 (6): 1741—9. PMID 12444048. doi:10.1095/biolreprod.101.002808. 
  • Morgan K; Conklin D; Pawson AJ; et al. (2003). „A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12”. Endocrinology. 144 (2): 423—36. PMID 12538601. doi:10.1210/en.2002-220622. 
  • Pawson AJ; Maudsley S; Morgan K; et al. (2005). „Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment”. Endocrinology. 146 (6): 2639—49. PMID 15761034. doi:10.1210/en.2005-0133. 
  • Eicke N; Günthert AR; Viereck V; et al. (2005). „GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs”. Eur. J. Endocrinol. 153 (4): 605—12. PMID 16189182. doi:10.1530/eje.1.02005. 
  • Ikemoto T, Park MK (2006). „Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors”. Genomics. 87 (4): 459—62. PMID 16406723. doi:10.1016/j.ygeno.2005.11.005. 
  • Parker JD, Malik M, Catherino WH (2007). „Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor”. Fertil. Steril. 88 (1): 39—46. PMID 17296196. doi:10.1016/j.fertnstert.2006.11.098. 

Spoljašnje veze[уреди]