GPR4

Из Википедије, слободне енциклопедије
G protein-spregnuti receptor 4
Identifikatori
Simboli GPR4;
Vanjski ID OMIM600551 MGI2441992 HomoloGene3867 IUPHAR: GPR4 GeneCards: GPR4 Gene
Pregled RNK izražavanja
PBB GE GPR4 206236 at tn.png
PBB GE GPR4 211266 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2828 319197
Ensembl ENSG00000177464 ENSMUSG00000044317
UniProt P46093 n/a
RefSeq (mRNA) NM_005282 NM_175668
RefSeq (protein) NP_005273 NP_783599
Lokacija (UCSC) Chr 19:
50.78 - 50.8 Mb
Chr 7:
18.37 - 18.38 Mb
PubMed pretraga [1] [2]

GPR4, G-protein spregnuti receptor 4, je protein koji je kod čoveka kodiran GPR4 genom.[1][2]

Vidi još[уреди]

Literatura[уреди]

  1. Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (1996). „Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3”. Genomics 30 (1): 84—8. doi:10.1006/geno.1995.0013. PMID 8595909. 
  2. „Entrez Gene: GPR4 G protein-coupled receptor 4”. 

Dodatna literatura[уреди]

  • An S, Tsai C, Goetzl EJ (1996). „Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.”. FEBS Lett. 375 (1-2): 121—4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. 
  • Heiber M, Docherty JM, Shah G; et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25—35. doi:10.1089/dna.1995.14.25. PMID 7832990. 
  • Zhu K, Baudhuin LM, Hong G; et al. (2001). „Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.”. J. Biol. Chem. 276 (44): 41325—35. doi:10.1074/jbc.M008057200. PMID 11535583. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Lum H, Qiao J, Walter RJ; et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786—9. doi:10.1152/ajpheart.00359.2003. PMID 12805023. 
  • Ludwig MG, Vanek M, Guerini D; et al. (2003). „Proton-sensing G-protein-coupled receptors.”. Nature 425 (6953): 93—8. doi:10.1038/nature01905. PMID 12955148. 
  • Bektas M, Barak LS, Jolly PS; et al. (2003). „The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.”. Biochemistry 42 (42): 12181—91. doi:10.1021/bi035051y. PMID 14567679. 
  • Sin WC, Zhang Y, Zhong W; et al. (2004). „G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.”. Oncogene 23 (37): 6299—303. doi:10.1038/sj.onc.1207838. PMID 15221007. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kim KS, Ren J, Jiang Y; et al. (2005). „GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.”. FASEB J. 19 (7): 819—21. doi:10.1096/fj.04-2988fje. PMID 15857892. 
  • Qiao J, Huang F, Naikawadi RP; et al. (2006). „Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91—101. doi:10.1152/ajplung.00508.2005. PMID 16461426. 
  • Huang F, Mehta D, Predescu S; et al. (2007). „A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.”. Endothelium 14 (1): 25—34. doi:10.1080/10623320601177288. PMID 17364894. 
  • Zou Y, Kim CH, Chung JH; et al. (2007). „Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.”. FEBS J. 274 (10): 2573—84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524. 
  • Tobo M, Tomura H, Mogi C; et al. (2007). „Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.”. Cell. Signal. 19 (8): 1745—53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.