ADCYAP1R1

Hipofizni adenilat ciklazno aktivirajući polipeptidni receptor tip I
Hipofizni adenilat ciklazno aktivirajući polipeptidni receptor tip I
Dostupne strukture
	2JOD, 3N94
Identifikatori
Simboli	ADCYAP1R1; PAC1; PAC1R; PACAPR; PACAPRI
Vanjski ID	OMIM: 102981 MGI: 108449 HomoloGene: 870 IUPHAR: PAC1 GeneCards: ADCYAP1R1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorska aktivnost; • aktivnost vazoaktivnog intestinalnog polipeptidnog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom;
Biološki proces	• ćelijska adhezija; • signalni put G protein spregnutog receptora; • signalni put tirozin kinaznog transmembranskog receptora; • aktivacija adenilat ciklaze; • multicelularni razvoj organizma; • spermatogeneza; • ćelijska diferencijacija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	117
Ensembl	ENSG00000078549
UniProt	P41586
RefSeq (mRNA)	NM_001118.4
RefSeq (protein)	NP_001109.2
Lokacija (UCSC)	Chr 7:; 31.09 - 31.15 Mb
PubMed pretraga	[1]

Hipofizni adenilat ciklazno aktivirajući polipeptidni receptor tip I (PAC₁) je protein koji je kod ljudi kodiran ADCYAP1R1 genom.^[1] Za ovaj receptor se vezuje hipofizni adenilat ciklazno aktivirajući peptid.^[2]^[3]

PAC₁ je za membranu vezani protein, koji je u znatnoj meri homologan sa članovima klase B G protein spregnutih glukagonskih/sekretinskih receptora. Ovaj receptor posreduje različita dejstva adenilat ciklazno aktivirajućeg polipeptida 1 i pozitivno je spregnut sa adenilat ciklazom. Alternativno splajsovanje dva eksona ovog gena proizvodi četiri glavne splajsne varijante.^[1] PAC₁ je izražen u nadbubrežnim žlezdama, pankreasu, materici, i mozgu.^[4]^[5]^[6]^[7]

Reference

^ ^а ^б „Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I”.
^ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (1993). „Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor”. Biochem. Biophys. Res. Commun. 196 (3): 1511—21. PMID 7902709. doi:10.1006/bbrc.1993.2423.
^ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (2000). „Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions”. Pharmacol. Rev. 52 (2): 269—324. PMID 10835102. Архивирано из оригинала 05. 07. 2008. г. Приступљено 04. 08. 2012.
^ JC, Reubi (2000). „In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications.”. Ann N Y Acad Sci. 921: 11193811. PMID 11193811. doi:10.1111/j.1749-6632.2000.tb06946.x.
^ Reubi JC, Laderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (2000). „Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin.”. Cancer Res. 60 (11): 3105—3112. PMID 10850463.
^ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (1998). „Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation”. J Clin Endocrinol Metab. 83 (4): 1299—1305. PMID 9543159. doi:10.1210/jc.83.4.1299.
^ Knutsson, M.; Edvinsson, L. (2002). „Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.”. Neuroreport. 13 (4): 507—9. PMID 11930171. doi:10.1097/00001756-200203250-00030.

Literatura

M, Stoffel; Espinosa R; Trabb JB (1995). „Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.”. Genomics. 23 (3): 697—9. PMID 7851900. doi:10.1006/geno.1994.1560.
K, Ogi; Miyamoto Y; Masuda Y (1994). „Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor.”. Biochem. Biophys. Res. Commun. 196 (3): 1511—21. PMID 7902709. doi:10.1006/bbrc.1993.2423.
T, Ohtaki; Masuda Y; Ishibashi Y (1994). „Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide.”. J. Biol. Chem. 268 (35): 26650—7. PMID 8253796.
Pisegna JR, Wank SA (1996). „Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.”. J. Biol. Chem. 271 (29): 17267—74. PMID 8663363. doi:10.1074/jbc.271.29.17267.
C, Pantaloni; Brabet P; Bilanges B (1996). „Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation.”. J. Biol. Chem. 271 (36): 22146—51. PMID 8703026. doi:10.1074/jbc.271.36.22146.
RM, Solano; Carmena MJ; Carrero I (1996). „Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate.”. Endocrinology. 137 (7): 2815—22. PMID 8770902. doi:10.1210/en.137.7.2815.
Wei Y, Mojsov S (1997). „Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology.”. J. Neuroendocrinol. 8 (11): 811—7. PMID 8933357. doi:10.1046/j.1365-2826.1996.05191.x.
P, Brabet; Diriong S; Journot L (1997). „Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization.”. Genomics. 38 (1): 100—2. PMID 8954788. doi:10.1006/geno.1996.0600.
L, Yon; Breault L; Contesse V (1998). „Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation.”. J. Clin. Endocrinol. Metab. 83 (4): 1299—305. PMID 9543159. doi:10.1210/jc.83.4.1299.
M, Steinhoff; McGregor GP; Radleff-Schlimme A (1999). „Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis.”. Regul. Pept. 80 (1–2): 49—55. PMID 10235634. doi:10.1016/S0167-0115(99)00010-5.
N, Zeng; Athmann C; Kang T (1999). „PACAP type I receptor activation regulates ECL cells and gastric acid secretion”. J. Clin. Invest. 104 (10): 1383—91. PMC 409843 . PMID 10562300. doi:10.1172/JCI7537.
Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (2000). „N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants”. J. Neuroendocrinol. 11 (12): 941—9. PMID 10583729. doi:10.1046/j.1365-2826.1999.00411.x.
ML, Scaldaferri; Modesti A; Palumbo C (2000). „Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta”. Endocrinology. 141 (3): 1158—67. PMID 10698193. doi:10.1210/en.141.3.1158.
R, Busto; Prieto JC; Bodega G (2000). „Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung”. Peptides. 21 (2): 265—9. PMID 10764955. doi:10.1016/S0196-9781(99)00202-8.
Knutsson M, Edvinsson L (2002). „Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia”. Neuroreport. 13 (4): 507—9. PMID 11930171. doi:10.1097/00001756-200203250-00030.
M, Miampamba; Germano PM; Arli S (2002). „Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons”. Regul. Pept. 105 (3): 145—54. PMID 11959368. doi:10.1016/S0167-0115(02)00003-4.
SV, Le; Yamaguchi DJ; McArdle CA (2003). „PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells”. Regul. Pept. 109 (1–3): 115—25. PMID 12409223. doi:10.1016/S0167-0115(02)00194-5.
E, Ronaldson; Robertson DN; Johnson MS (2003). „Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF”. Regul. Pept. 109 (1–3): 193—8. PMID 12409233. doi:10.1016/S0167-0115(02)00204-5.
RL, Strausberg; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
K, Isobe; Tatsuno I; Yashiro T (2003). „Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis”. Regul. Pept. 110 (3): 213—7. PMID 12573802. doi:10.1016/S0167-0115(02)00209-4.

Spoljašnje veze

„VIP and PACAP Receptors: PAC₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 27. 12. 2015. г.

[entrez-1] а ^б „Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I”.

[pmid7902709-2] Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (1993). „Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor”. Biochem. Biophys. Res. Commun. 196 (3): 1511—21. PMID 7902709. doi:10.1006/bbrc.1993.2423.

[pmid10835102-3] Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (2000). „Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions”. Pharmacol. Rev. 52 (2): 269—324. PMID 10835102. Архивирано из оригинала 05. 07. 2008. г. Приступљено 04. 08. 2012.

[pmid11193811-4] JC, Reubi (2000). „In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications.”. Ann N Y Acad Sci. 921: 11193811. PMID 11193811. doi:10.1111/j.1749-6632.2000.tb06946.x.

[pmid10850463-5] Reubi JC, Laderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (2000). „Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin.”. Cancer Res. 60 (11): 3105—3112. PMID 10850463.

[pmid9543159-6] Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (1998). „Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation”. J Clin Endocrinol Metab. 83 (4): 1299—1305. PMID 9543159. doi:10.1210/jc.83.4.1299.

[Knutsson-2002-7] Knutsson, M.; Edvinsson, L. (2002). „Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.”. Neuroreport. 13 (4): 507—9. PMID 11930171. doi:10.1097/00001756-200203250-00030.

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