GPR182

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G protein spregnuti receptor 182
Identifikatori
Simboli GPR182; 7TMR; AMR; MGC34399; gamrh; hrhAMR
Vanjski ID OMIM605307 MGI109545 HomoloGene5255 IUPHAR: GPR182 GeneCards: GPR182 Gene
Pregled RNK izražavanja
PBB GE ADMR 214506 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 11318 11536
Ensembl ENSG00000166856 n/a
UniProt O15218 n/a
RefSeq (mRNA) NM_007264 NM_007412
RefSeq (protein) NP_009195 NP_031438
Lokacija (UCSC) Chr 12:
55.67 - 55.68 Mb
n/a
PubMed pretraga [1] [2]

GPR182 (ili G protein spregnuti receptor 182) je ljudski gen (i asocirani protein) koji je orfan GPCR.[1]

Kad je ovaj gen bio kloniran prvi put, pretpostavljeno je da kodira adrenomedulin receptor.[2] Međutim kad je korespondirajući protein izražen, utvrđeno je da ne proizvodi respons na adrenomedulin (ADM).[3]

Naknadno je bilo pokazano da jedan drugi GPCR receptor, CALCRL u kompleksu sa RAMP2 može da funkcioniše kao ADM receptor.[4]

Literatura[уреди]

  1. ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003). „The G protein-coupled receptor repertoires of human and mouse”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903—8. PMC 153653Слободан приступ. PMID 12679517. doi:10.1073/pnas.0230374100. 
  2. ^ Hänze J, Dittrich K, Dötsch J, Rascher W (1997). „Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system”. Biochem. Biophys. Res. Commun. 240 (1): 183—8. PMID 9367907. doi:10.1006/bbrc.1997.7631. 
  3. ^ Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (1998). „Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response”. Biochem. Biophys. Res. Commun. 244 (3): 832—7. PMID 9535752. doi:10.1006/bbrc.1998.8349. 
  4. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). „RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor”. Nature. 393 (6683): 333—9. PMID 9620797. doi:10.1038/30666. 

Dodatna literatura[уреди]

  • Lah JJ, Frishman WH (2002). „Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential.”. Heart disease (Hagerstown, Md.). 2 (3): 259—65. PMID 11728267. 
  • Mukoyama M; Sugawara A; Nagae T; et al. (2002). „Role of adrenomedullin and its receptor system in renal pathophysiology.”. Peptides. 22 (11): 1925—31. PMID 11754983. doi:10.1016/S0196-9781(01)00525-3. 
  • Fowler DE, Wang P (2002). „The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).”. Int. J. Mol. Med. 9 (5): 443—9. PMID 11956648. 
  • Kato J, Kitamura K, Kangawa K, Eto T (1995). „Receptors for adrenomedullin in human vascular endothelial cells.”. Eur. J. Pharmacol. 289 (2): 383—5. PMID 7621913. doi:10.1016/0922-4106(95)90117-5. 
  • Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). „Adrenomedullin receptor expression in human lung and in pulmonary tumors.”. J. Histochem. Cytochem. 45 (2): 159—64. PMID 9016306. 
  • Hänze J, Dittrich K, Dötsch J, Rascher W (1997). „Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.”. Biochem. Biophys. Res. Commun. 240 (1): 183—8. PMID 9367907. doi:10.1006/bbrc.1997.7631. 
  • Martínez A; Elsasser TH; Muro-Cacho C; et al. (1997). „Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument.”. Endocrinology. 138 (12): 5597—604. PMID 9389548. doi:10.1210/en.138.12.5597. 
  • Kennedy SP; Sun D; Oleynek JJ; et al. (1998). „Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.”. Biochem. Biophys. Res. Commun. 244 (3): 832—7. PMID 9535752. doi:10.1006/bbrc.1998.8349. 
  • Jiménez N; Calvo A; Martínez A; et al. (1999). „Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate.”. J. Histochem. Cytochem. 47 (9): 1167—78. PMID 10449538. 
  • Kuwasako K; Kitamura K; Ito K; et al. (2002). „The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors.”. J. Biol. Chem. 276 (52): 49459—65. PMID 11591721. doi:10.1074/jbc.M108369200. 
  • Forneris M; Gottardo L; Albertin G; et al. (2002). „Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.”. Int. J. Mol. Med. 8 (6): 675—9. PMID 11712085. 
  • Hänze J; Groneberg DA; Rose F; et al. (2002). „Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.”. Biochem. Biophys. Res. Commun. 291 (5): 1160—5. PMID 11883938. doi:10.1006/bbrc.2002.6595. 
  • Dumont CE; Muff R; Flühmann B; et al. (2003). „Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.”. Brain Res. 955 (1-2): 64—71. PMID 12419522. doi:10.1016/S0006-8993(02)03365-6. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Chosa E; Hamada H; Kitamura K; et al. (2003). „Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.”. Biochem. Biophys. Res. Commun. 303 (1): 379—86. PMID 12646214. doi:10.1016/S0006-291X(03)00347-4. 
  • Xu P; Dai AG; Zhou HD; et al. (2004). „[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]”. Zhonghua Jie He He Hu Xi Za Zhi. 26 (12): 765—8. PMID 14720432. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 

Spoljašnje veze[уреди]

  • „GPR182”. IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 04. 12. 2007. Приступљено 23. 08. 2010.