P2RY4
| Pirimidinski receptor P2Y, G-protein spregnuti, 4 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | P2RY4; NRU; P2P; P2Y4; UNR | ||
| Vanjski ID | OMIM: 300038 MGI: 1926594 HomoloGene: 20568 IUPHAR: P2Y4 GeneCards: P2RY4 Gene | ||
| Pregled RNK izražavanja | |||
 | |||
| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 5030 | 57385 | |
| Ensembl | ENSG00000186912 | ENSMUSG00000044359 | |
| UniProt | P51582 | Q0VBT7 | |
| RefSeq (mRNA) | NM_002565 | NM_020621 | |
| RefSeq (protein) | NP_002556 | NP_065646 | |
| Lokacija (UCSC) |
Chr X: 69.39 - 69.4 Mb |
Chr X: 96.79 - 96.8 Mb | |
| PubMed pretraga | [1] | [2] | |
P2Y purinoceptor 4 je protein koji je kod ljudi kodiran P2RY4 genom.[1][2]
Proizvod ovog gena, P2Y4, pripada familiji G-protein spregnutih receptora. Ova grupa sadrži više tipova receptora sa različitom farmakološkim selektivnostima za razne adenozinske i uridinske nukleotide, koje se preklapaju u nekim slučajevima. Ovaj receptor je responsivan na uridinske nukleotide, posebno na ATP, i nije responsivan na ADP.[2]
Vidi još
[уреди | уреди извор]Literatura
[уреди | уреди извор]- ^ Communi D, Pirotton S, Parmentier M, Boeynaems JM (1996). . „Cloning and functional expression of a human uridine nucleotide receptor”. J Biol Chem. 270 (52): 30849—52. PMID 8537336. doi:10.1074/jbc.270.52.30849.
- ^ а б „Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4”.
Dodatna literatura
[уреди | уреди извор]- Nguyen T; Erb L; Weisman GA; et al. (1996). . „Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene.”. J. Biol. Chem.. 270 (52): 30845—8. PMID 8537335. doi:10.1074/jbc.270.52.30845.
- Stam NJ, Klomp J, Van de Heuvel N, Olijve W (1996). . „Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor.”. FEBS Lett.. 384 (3): 260—4. PMID 8617367. doi:10.1016/0014-5793(96)00321-3.
- Nicholas RA; Watt WC; Lazarowski ER; et al. (1996). . „Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.”. Mol. Pharmacol.. 50 (2): 224—9. PMID 8700127.
- Maier R, Glatz A, Mosbacher J, Bilbe G (1997). . „Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.”. Biochem. Biophys. Res. Commun.. 237 (2): 297—302. PMID 9268704. doi:10.1006/bbrc.1997.7135.
- Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). . „Distribution of P2Y receptor subtypes on haematopoietic cells.”. Br. J. Pharmacol.. 123 (5): 789—94. PMC 1565225
. PMID 9535005. doi:10.1038/sj.bjp.0701665. - Brinson AE, Harden TK (2001). . „Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.”. J. Biol. Chem.. 276 (15): 11939—48. PMID 11114308. doi:10.1074/jbc.M009909200.
- Suarez-Huerta N, Pouillon V, Boeynaems J, Robaye B (2001). . „Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor.”. Eur. J. Pharmacol.. 416 (3): 197—202. PMID 11290369. doi:10.1016/S0014-2999(01)00875-5.
- Moore DJ; Chambers JK; Wahlin JP; et al. (2001). . „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID 11690642.
- Idzko M; Dichmann S; Ferrari D; et al. (2002). . „Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.”. Blood. 100 (3): 925—32. PMID 12130504. doi:10.1182/blood.V100.3.925.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). . „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). . „Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.”. J. Invest. Dermatol.. 120 (3): 440—7. PMID 12603858. doi:10.1046/j.1523-1747.2003.12050.x.
- Kim SG; Soltysiak KA; Gao ZG; et al. (2003). . „Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.”. Biochem. Pharmacol.. 65 (6): 923—31. PMID 12623123. doi:10.1016/S0006-2952(02)01614-3.
- Herold CL, Qi AD, Harden TK, Nicholas RA (2004). . „Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.”. J. Biol. Chem.. 279 (12): 11456—64. PMC 1821344 . PMID 14670966. doi:10.1074/jbc.M301734200.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). . „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Cavaliere F; Nestola V; Amadio S; et al. (2005). . „The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.”. Neurobiol. Dis.. 18 (1): 100—9. PMID 15649700. doi:10.1016/j.nbd.2004.09.001.
- Ross MT; Grafham DV; Coffey AJ; et al. (2005). . „The DNA sequence of the human X chromosome.”. Nature. 434 (7031): 325—37. PMC 2665286 . PMID 15772651. doi:10.1038/nature03440.
Spoljašnje veze
[уреди | уреди извор]- „P2Y Receptors: P2Y4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г..
