Dopaminski receptor D5

Из Википедије, слободне енциклопедије
Dopaminski receptor D5
Identifikatori
Simboli DRD5; DBDR; DRD1B; DRD1L2
Vanjski ID OMIM126453 MGI94927 HomoloGene20216 IUPHAR: D5 GeneCards: DRD5 Gene
Pregled RNK izražavanja
PBB GE DRD5 208486 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1816 13492
Ensembl ENSG00000169676 ENSMUSG00000039358
UniProt P21918 Q8BLD9
RefSeq (mRNA) NM_000798.4 NM_013503.2
RefSeq (protein) NP_000789.1 NP_038531.1
Lokacija (UCSC) Chr 4:
9.78 - 9.79 Mb
Chr 5:
38.71 - 38.71 Mb
PubMed pretraga [1] [2]

D(1B) dopaminski receptor je protein koji je kod ljudi kodiran DRD5 genom.[1][2][3]

Dopaminski D5 podtip je G protein spregnuti receptor koji stimuliše adenilil ciklazu.[4] Ovaj receptor je izražen u neuronima limbičkog regiona mozga. On ima 10-puta veći afinitet za dopamin nego D1 podtip. Pseudogeni srodni sa ovim genom se nalaze na hromozomu 1 i hromozomu 2.[2]

Ligandi[уреди]

D1 i D5 receptori su u znatnoj meri strukturno homologni i mali broj selektivnih liganda je dostupan. Postoje brojni ligandi koji su selektivni za D1/5 u odnosu na druge dopaminske receptore. Nedavni razvoj selektivnog D5 antagonista je omogućio ispitivanje D1-posredovanog odgovora u odsustvu D5 komponente. Selektivni D5 agonisti trenutno nisu dostupni.

Agonist[уреди]

Antagonist[уреди]

  • 4-Hloro-7-metil-5,6,7,8,9,14-heksahidrodibenz[d,g]azecin-3-ol: antagonist, umerena selektivnost vezivanja u odnosu na D1[5]
Hemijska struktura D5 selektivnog liganda 4-hloro-7-metil-5,6,7,8,9,14-heksahidrodibenz[d,g]azecin-3-ol.[5]

Interakcije[уреди]

Za dopaminski receptor D5 je pokazano da interaguje sa GABRG2.[6]

Reference[уреди]

  1. Polymeropoulos MH, Xiao H, Merril CR (1992). „The human D5 dopamine receptor (DRD5) maps on chromosome 4”. Genomics. 11 (3): 777—778. doi:10.1016/0888-7543(91)90091-R. PMID 1774076. 
  2. 2,0 2,1 „Entrez Gene: DRD5 dopamine receptor D5”. 
  3. Polymeropoulos MH, Xiao H, Merril CR (1991). „The human D5 dopamine receptor (DRD5) maps on chromosome 4”. Genomics. 11 (3): 777—778. doi:10.1016/0888-7543(91)90091-R. PMID 1774076. 
  4. Sidhu A (1998). „Coupling of D1 and D5 dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling”. Mol. Neurobiol. 16 (2): 125—134. doi:10.1007/BF02740640. PMID 9588624. 
  5. 5,0 5,1 Mohr P, Decker M, Enzensperger C, Lehmann J (2006). „Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist”. J. Med. Chem. 49 (6): 2110—2116. doi:10.1021/jm051237e. PMID 16539400. 
  6. Liu, F; Wan Q, Pristupa Z B, Yu X M, Wang Y T, Niznik H B (2000). „Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors”. Nature. England. 403 (6767): 274—280. doi:10.1038/35002014. ISSN 0028-0836. PMID 10659839. 

Literatura[уреди]

  • Missale C; Nash SR; Robinson SW; et al. (1998). „Dopamine receptors: from structure to function”. Physiol. Rev. 78 (1): 189—225. PMID 9457173. 
  • Grandy DK; Allen LJ; Zhang Y; et al. (1992). „Chromosomal localization of three human D5 dopamine receptor genes”. Genomics. 13 (4): 968—973. doi:10.1016/0888-7543(92)90009-H. PMID 1387108. 
  • Eubanks JH; Altherr M; Wagner-McPherson C; et al. (1992). „Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus”. Genomics. 12 (3): 510—516. doi:10.1016/0888-7543(92)90442-U. PMID 1532789. 
  • Sunahara RK; Guan HC; O'Dowd BF; et al. (1991). „Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1”. Nature. 350 (6319): 614—619. doi:10.1038/350614a0. PMID 1826762. 
  • Tiberi M; Jarvie KR; Silvia C; et al. (1991). „Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor”. Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491—7495. doi:10.1073/pnas.88.17.7491. PMC 52326слободно за читање. PMID 1831904. 
  • Grandy DK; Zhang YA; Bouvier C; et al. (1991). „Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes”. Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9175—9179. doi:10.1073/pnas.88.20.9175. PMC 52675слободно за читање. PMID 1833775. 
  • Weinshank RL; Adham N; Macchi M; et al. (1991). „Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene”. J. Biol. Chem. 266 (33): 22427—35. PMID 1834671. 
  • Sobell JL; Lind TJ; Sigurdson DC; et al. (1995). „The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease”. Hum. Mol. Genet. 4 (4): 507—514. doi:10.1093/hmg/4.4.507. PMID 7633397. 
  • Beischlag TV; Marchese A; Meador-Woodruff JH; et al. (1995). „The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region”. Biochemistry. 34 (17): 5960—5970. doi:10.1021/bi00017a025. PMID 7727453. 
  • Sherrington R; Mankoo B; Attwood J; et al. (1994). „Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1”. Genomics. 18 (2): 423—425. doi:10.1006/geno.1993.1489. PMID 8288248. 
  • Sidhu A; Kimura K; Uh M; et al. (1998). „Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz”. J. Neurochem. 70 (6): 2459—2467. doi:10.1046/j.1471-4159.1998.70062459.x. PMID 9603210. 
  • Cargill M; Altshuler D; Ireland J; et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes”. Nat. Genet. 22 (3): 231—238. doi:10.1038/10290. PMID 10391209. 
  • Liu F; Wan Q; Pristupa ZB; et al. (2000). „Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors”. Nature. 403 (6767): 274—280. doi:10.1038/35002014. PMID 10659839. 
  • Misbahuddin A; Placzek MR; Chaudhuri KR; et al. (2004). „A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm”. Neurology. 58 (1): 124—6. PMID 11781417. 
  • Kabbani N; Negyessy L; Lin R; et al. (2002). „Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor”. J. Neurosci. 22 (19): 8476—86. PMID 12351722. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—16903. doi:10.1073/pnas.242603899. PMC 139241слободно за читање. PMID 12477932. 
  • Hemby SE, Trojanowski JQ, Ginsberg SD (2003). „Neuron-specific age-related decreases in dopamine receptor subtype mRNAs”. J. Comp. Neurol. 456 (2): 176—183. doi:10.1002/cne.10525. PMID 12509874. 
  • Zheng S; Yu P; Zeng C; et al. (2003). „Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron”. Hypertension. 41 (3): 604—610. doi:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966. 

Vidi još[уреди]

Spoljašnje veze[уреди]