Receptor paratiroidnog hormona 2

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Receptor paratiroidnog hormona 2
Identifikatori
Simboli PTH2R; PTHR2
Vanjski ID OMIM601469 MGI2180917 HomoloGene3701 IUPHAR: PTH2 GeneCards: PTH2R Gene
Pregled RNK izražavanja
PBB GE PTHR2 206772 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5746 213527
Ensembl ENSG00000144407 ENSMUSG00000025946
UniProt P49190 Q91V95
RefSeq (mRNA) NM_005048.2 NM_139270.2
RefSeq (protein) NP_005039.1 NP_644676.1
Lokacija (UCSC) Chr 2:
209.22 - 209.72 Mb
Chr 1:
65.33 - 65.44 Mb
PubMed pretraga [1] [2]

Parathyroid hormone 2 receptor je protein koji je kod ljudi kodiran PTH2R genom[1]

Funkcija[уреди]

Ovaj protein je član familije 2 G protein spregnutih receptora. On je receptor za paratiroidni hormon (PTH). Ovaj receptor je selektiviji u prepoznavanju liganda i ima specifičniju tkivnu distribuciju u poređenju sa receptorom paratiroidnog hormona 2 (PTH1R). On se aktivira samo posredstvom PTH, a ne i PTHLH. on je posebno zastupljen u mozgu i pankreasu.[1]

Reference[уреди]

  1. 1,0 1,1 „Entrez Gene: PTH2R parathyroid hormone 2 receptor”.  Грешка цитата: Invalid <ref> tag; name "entrez" defined multiple times with different content

Literatura[уреди]

  • Usdin TB, Gruber C, Bonner TI (1995). „Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.”. J. Biol. Chem. 270 (26): 15455—8. doi:10.1074/jbc.270.26.15455. PMID 7797535. 
  • Usdin TB, Modi W, Bonner TI (1997). „Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.”. Genomics. 37 (1): 140—1. doi:10.1006/geno.1996.0532. PMID 8921382. 
  • Clark JA, Bonner TI, Kim AS, Usdin TB (1998). „Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.”. Mol. Endocrinol. 12 (2): 193—206. doi:10.1210/me.12.2.193. PMID 9482662. 
  • Hoare SR, Clark JA, Usdin TB (2000). „Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.”. J. Biol. Chem. 275 (35): 27274—83. doi:10.1074/jbc.M003910200. PMID 10854439. 
  • John MR; Arai M; Rubin DA; et al. (2002). „Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.”. Endocrinology. 143 (3): 1047—57. doi:10.1210/en.143.3.1047. PMID 11861531. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241Слободан приступ. PMID 12477932. 
  • Seeliger S; Hausberg M; Eue I; et al. (2003). „The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.”. Clin. Nephrol. 59 (6): 429—35. PMID 12834174. 
  • Bisello A; Manen D; Pierroz DD; et al. (2004). „Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.”. Mol. Endocrinol. 18 (6): 1486—98. doi:10.1210/me.2003-0487. PMID 14988434. 
  • Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928Слободан приступ. PMID 15489334. 
  • Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.”. FEBS Lett. 579 (3): 803—7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. 

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