LPAR5

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Receptor lizofosfatidne kiseline 5
Identifikatori
Simboli LPAR5; GPR92 ; GPR93; KPG_010; LPA5
Vanjski ID OMIM606926 MGI2685918 HomoloGene10696 IUPHAR: GeneCards: LPAR5 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 57121 381810
Ensembl ENSG00000184574 ENSMUSG00000067714
UniProt Q9H1C0 n/a
RefSeq (mRNA) NM_020400 XM_355812
RefSeq (protein) NP_065133 XP_355812
Lokacija (UCSC) Chr 12:
6.6 - 6.62 Mb
Chr 6:
125.03 - 125.05 Mb
PubMed pretraga [1] [2]

LPA5, receptor lizofosfatidne kiseline 5, je protein koji je kod čoveka kodiran LPAR5 gena.[1][2][3][4][5] LPA5 je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).[6]

Vidi još[уреди]

Literatura[уреди]

  1. ^ Adhr, Consortium; Strom, Tim M.; White, Kenneth E.; Evans, Wayne E.; O'Riordan, Jeffery L.H.; Speer, Marcy C.; Lorenz-Depiereux, Bettina; Grabowski, Monika; Meitinger, Thomas (2000). „Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23”. Nat Genet. 26 (3): 345—8. PMID 11062477. doi:10.1038/81664. 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene. 275 (1): 83—91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5. 
  3. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (2006). „GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5”. J Biol Chem. 281 (33): 23589—97. PMID 16774927. doi:10.1074/jbc.M603670200. 
  4. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B (2006). „Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes”. J Pharmacol Exp Ther. 318 (2): 619—28. PMID 16651401. doi:10.1124/jpet.105.098848. 
  5. ^ „Entrez Gene: GPR92 G protein-coupled receptor 92”. 
  6. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology. 50 (1): 157—186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753. 

Dodatna literatura[уреди]