TAS2R14
| Receptor ukusa tip 2 član 14 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | TAS2R14; T2R14; TRB1 | ||||||||||
| Vanjski ID | OMIM: 604790 MGI: 2681298 HomoloGene: 87013 IUPHAR: GeneCards: TAS2R14 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 50840 | 387616 | |||||||||
| Ensembl | ENSG00000212127 | ENSMUSG00000071147 | |||||||||
| UniProt | Q9NYV8 | Q7TQA4 | |||||||||
| RefSeq (mRNA) | NM_023922.1 | NM_021562.1 | |||||||||
| RefSeq (protein) | NP_076411.1 | NP_067537.1 | |||||||||
| Lokacija (UCSC) |
Chr 12: 11.09 - 11.32 Mb |
Chr 6: 133 - 133.01 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor ukusa tip 2 član 14 je protein koji je kod ljudi kodiran TAS2R14 genom.[1][2][3]
Funkcije
[уреди | уреди извор]Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Istraživanja funkcionalne ekspresije su pokazala da TAS2R14 proizvodi respons na (-)-α-tujon, primarni neurotoksični agens u absintu, i pikrotoksinu, otrovu prisutnom u bobicama biljke Anamirta cocculus.[4] Ovaj gen se nalazi u genskom klasteru na hromozomu 12p13.[3]
Reference
[уреди | уреди извор]- ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
- ^ Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse”. Nature. 404 (6778): 601—4. PMID 10766242. doi:10.1038/35007072.
- ^ а б „Entrez Gene: TAS2R14 taste receptor, type 2, member 14”.
- ^ Behrens, M., A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig, and W. Meyerhof (2004). „The human taste receptor hTAS2R14 responds to a variety of different bitter compounds”. Biochem Biophys Res Commun. 319 (2): 479—485. PMID 15178431. doi:10.1016/j.bbrc.2004.05.019.
Literatura
[уреди | уреди извор]- Kinnamon SC (2000). „A plethora of taste receptors”. Neuron. 25 (3): 507—10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
- Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
- Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
- Chandrashekar J; Mueller KL; Hoon MA; et al. (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
- Liu T; Qian WJ; Gritsenko MA; et al. (2006). „Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry”. J. Proteome Res. 4 (6): 2070—80. PMC 1850943 . PMID 16335952. doi:10.1021/pr0502065.
- Behrens M; Bartelt J; Reichling C; et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression”. J. Biol. Chem. 281 (29): 20650—9. PMID 16720576. doi:10.1074/jbc.M513637200.
