Tromboksanski receptor

Tromboksanski A2 receptor
Tromboksanski A2 receptor
Identifikatori
Simboli	TBXA2R; TXA2-R
Vanjski ID	OMIM: 188070 MGI: 98496 HomoloGene: 825 IUPHAR: TP GeneCards: TBXA2R Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost tromboksanskog receptora; • aktivnost tromboksanskog A2 receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • membrana; • integralno sa membranom;
Biološki proces	• kontrakcija mišića; • prenos signala; • signalni put G-protein spregnutog receptora; • razmena respiratornih gasova;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	6915
Ensembl	ENSG00000006638
UniProt	P21731
RefSeq (mRNA)	NM_001060
RefSeq (protein)	NP_001051
Lokacija (UCSC)	Chr 19:; 3.55 - 3.56 Mb
PubMed pretraga	[1]

Tromboksanski receptor je protein na površini ćelija u endotelu krvnih sudova i posteljice koji interaguje sa eikozanoidnim lipidom tromboksanom. On je G-protein spregnuti receptor koji vezuje G protein G_q.^[1]

Gen

Gen tromboksanskog receptora, TBXA2R, se nalazi na hromozomu 19 i sadrži 15 kilobaza. Tromboksan je potentan stimulator agregacije trombocita i formiranja ugrušaka, a isto tako ima ulogu u vaskularnom tonusu.^[2] Tromboksanski receptor je član familije G protein-spregnutih receptora. Mutacije ovog receptora mogu da dovedu do poremećaja krvarenja.

Vidi još

Eikozanoidni receptor

Literatura

^ Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K (1995). . „Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization”. J. Clin. Invest.. 96 (2): 657—64. PMC 185246 . PMID 7635958. doi:10.1172/JCI118108. ^{[мртва веза]}
^ Michael P. Walsh; et all. . „Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697” (PDF). Архивирано из оригинала (PDF) 13. 07. 2011. г. Приступљено 02. 03. 2011.

Spoljašnje veze

„Prostanoid Receptors: TP”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г..

Dodatna literatura

Namba T, Narumiya S (1993). . „[Thromboxane A2 receptor; structure, function and tissue distribution]”. Nippon Rinsho. 51 (1): 233—40. PMID 8433523.
Murugappan S, Shankar H, Kunapuli SP (2005). . „Platelet receptors for adenine nucleotides and thromboxane A2.”. Semin. Thromb. Hemost.. 30 (4): 411—8. PMID 15354262. doi:10.1055/s-2004-833476.
Hirata M; Hayashi Y; Ushikubi F; et al. (1991). . „Cloning and expression of cDNA for a human thromboxane A2 receptor.”. Nature. 349 (6310): 617—20. PMID 1825698. doi:10.1038/349617a0.
Raychowdhury MK; Yukawa M; Collins LJ; et al. (1995). . „Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.”. J. Biol. Chem.. 270 (12): 7011. PMID 7896853. doi:10.1074/jbc.270.12.7011.
Hirata T; Kakizuka A; Ushikubi F; et al. (1994). . „Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.”. J. Clin. Invest.. 94 (4): 1662—7. PMC 295328 . PMID 7929844. doi:10.1172/JCI117510.
D'Angelo DD, Davis MG, Ali S, Dorn GW (1994). . „Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells.”. J. Pharmacol. Exp. Ther.. 271 (2): 1034—41. PMID 7965765.
Raychowdhury MK; Yukawa M; Collins LJ; et al. (1994). . „Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.”. J. Biol. Chem.. 269 (30): 19256—61. PMID 8034687.
Borg C; Lim CT; Yeomans DC; et al. (1994). . „Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies.”. J. Biol. Chem.. 269 (8): 6109—16. PMID 8119956.
Nüsing RM; Hirata M; Kakizuka A; et al. (1993). . „Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.”. J. Biol. Chem.. 268 (33): 25253—9. PMID 8227091.
Funk CD, Furci L, Moran N, Fitzgerald GA (1994). . „Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites.”. Mol. Pharmacol.. 44 (5): 934—9. PMID 8246916.
Schwengel DA, Nouri N, Meyers DA, Levitt RC (1994). . „Linkage mapping of the human thromboxane A2 receptor (TBXA2R) to chromosome 19p13.3 using transcribed 3' untranslated DNA sequence polymorphisms.”. Genomics. 18 (2): 212—5. PMID 8288221. doi:10.1006/geno.1993.1457.
Offermanns S, Laugwitz KL, Spicher K, Schultz G (1994). . „G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.”. Proc. Natl. Acad. Sci. U.S.A.. 91 (2): 504—8. PMC 42977 . PMID 8290554. doi:10.1073/pnas.91.2.504.
Hirata T; Ushikubi F; Kakizuka A; et al. (1996). . „Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.”. J. Clin. Invest.. 97 (4): 949—56. PMC 507140 . PMID 8613548. doi:10.1172/JCI118518.
Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). . „The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.”. J. Pharmacol. Exp. Ther.. 281 (2): 957—64. PMID 9152406.
Becker KP, Garnovskaya M, Gettys T, Halushka PV (1999). . „Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.”. Biochim. Biophys. Acta. 1450 (3): 288—96. PMID 10395940. doi:10.1016/S0167-4889(99)00068-3.
Barr CL; Wigg KG; Pakstis AJ; et al. (1999). . „Genome scan for linkage to Gilles de la Tourette syndrome.”. Am. J. Med. Genet.. 88 (4): 437—45. PMID 10402514. doi:10.1002/(SICI)1096-8628(19990820)88:4<437::AID-AJMG24>3.0.CO;2-E.
Zhou H, Yan F, Tai HH (2001). . „Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.”. J. Pharmacol. Exp. Ther.. 298 (3): 1243—51. PMID 11504827.
Vezza R, Mezzasoma AM, Venditti G, Gresele P (2002). . „Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.”. Thromb. Haemost.. 87 (1): 114—21. PMID 11848439.
Turek JW; Halmos T; Sullivan NL; et al. (2002). . „Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.”. J. Biol. Chem.. 277 (19): 16791—7. PMID 11877412. doi:10.1074/jbc.M105872200.

[pmid7635958-1] Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K (1995). . „Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization”. J. Clin. Invest.. 96 (2): 657—64. PMC 185246 . PMID 7635958. doi:10.1172/JCI118108. ^{[мртва веза]}

[2] Michael P. Walsh; et all. . „Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697” (PDF). Архивирано из оригинала (PDF) 13. 07. 2011. г. Приступљено 02. 03. 2011.

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