MAS1

Из Википедије, слободне енциклопедије
MAS1 onkogen
Identifikatori
Simboli MAS1; MAS; MGC119966
Vanjski ID OMIM165180 MGI96918 HomoloGene1782 IUPHAR: MAS1 GeneCards: MAS1 Gene
Pregled RNK izražavanja
PBB GE MAS1 208210 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4142 17171
Ensembl ENSG00000130368 ENSMUSG00000068037
UniProt P04201 Q0VB49
RefSeq (mRNA) NM_002377 XM_622557
RefSeq (protein) NP_002368 XP_622557
Lokacija (UCSC) Chr 6:
160.25 - 160.25 Mb
Chr 17:
12.68 - 12.69 Mb
PubMed pretraga [1] [2]

MAS proto-onkogen je protein koji je kod ljudi kodiran MAS1 genom.[1]

MAS1 struktura sugestira da ovaj protein pripada klasi receptora koji su spregnuti sa GTP-vezujućim proteinima. MAS1 poseduje GPCR 7-TM konzervirani strukturni motiv. Ovaj zaključak je uzveden na osnovu predviđenih hidrofobinih segmenta koji su tipični za spoljašnje strane transmembranskog alfa-heliksnog svežnja. Pretpostavlja se da aktivirani MAS1 receptor modulira jednu od kritičnih komponenti signalnog puta regulacije rasta.[1]

Vidi još[уреди]

Literatura[уреди]

Dodatna literatura[уреди]

  • Hanley MR (1992). „Molecular and cell biology of angiotensin receptors.”. J. Cardiovasc. Pharmacol. 18 Suppl 2: S7—13. PMID 1725048. 
  • Hanley MR, Cheung WT, Hawkins P; et al. (1990). „The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.”. Ciba Found. Symp. 150: 23—38; discussion 38—46. PMID 2197067. 
  • Rabin M, Birnbaum D, Young D; et al. (1988). „Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements.”. Oncogene Res. 1 (2): 169—78. PMID 3329713. 
  • Jackson TR, Blair LA, Marshall J; et al. (1988). „The mas oncogene encodes an angiotensin receptor.”. Nature. 335 (6189): 437—40. doi:10.1038/335437a0. PMID 3419518. 
  • Young D, Waitches G, Birchmeier C; et al. (1986). „Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.”. Cell. 45 (5): 711—9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. 
  • Riesewijk AM, Schepens MT, Mariman EM; et al. (1996). „The MAS proto-oncogene is not imprinted in humans.”. Genomics. 35 (2): 380—2. doi:10.1006/geno.1996.0372. PMID 8661154. 
  • Xu X, Quiambao AB, Roveri L; et al. (2000). „Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene.”. Exp. Neurol. 163 (1): 207—19. doi:10.1006/exnr.2000.7370. PMID 10785460. 
  • Alenina N, Baranova T, Smirnow E; et al. (2002). „Cell type-specific expression of the Mas proto-oncogene in testis.”. J. Histochem. Cytochem. 50 (5): 691—6. PMID 11967280. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241слободно за читање. PMID 12477932. 
  • Santos RA, Simoes e Silva AC, Maric C; et al. (2003). „Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.”. Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258—63. doi:10.1073/pnas.1432869100. PMC 166216слободно за читање. PMID 12829792. 
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature. 425 (6960): 805—11. doi:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928слободно за читање. PMID 15489334. 
  • Canals M, Jenkins L, Kellett E, Milligan G (2006). „Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.”. J. Biol. Chem. 281 (24): 16757—67. doi:10.1074/jbc.M601121200. PMID 16611642.