Somatostatinski receptor 2

Из Википедије, слободне енциклопедије
Somatostatinski receptor 2
Identifikatori
Simboli SSTR2;
Vanjski ID OMIM182452 MGI98328 HomoloGene37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
Pregled RNK izražavanja
PBB GE SSTR2 214597 at tn.png
PBB GE SSTR2 217455 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6752 20606
Ensembl ENSG00000180616 ENSMUSG00000047904
UniProt P30874 P30875
RefSeq (mRNA) NM_001050 NM_009217
RefSeq (protein) NP_001041 NP_033243
Lokacija (UCSC) Chr 17:
68.67 - 68.68 Mb
Chr 11:
113.44 - 113.44 Mb
PubMed pretraga [1] [2]

Somatostatinski receptor tip 2 je protein koji je kod čoveka kodiran SSTR2 genom..[1]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR2 u znatnoj meri izražen u velikom mozgu i bubrezima.[2]

Interakcije[уреди]

Za somatostatinski receptor 2 je pokazano interaguje sa SHANK2.[3]

Vidi isto[уреди]

Literatura[уреди]

  1. Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics 15 (2): 449—52. doi:10.1006/geno.1993.1088. PMID 8449518. 
  2. „Entrez Gene: SSTR2 somatostatin receptor 2”. 
  3. Zitzer, H; Hönck H H, Bächner D, Richter D, Kreienkamp H J (1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. (UNITED STATES) 274 (46): 32997—3001. doi:10.1074/jbc.274.46.32997. ISSN 0021-9258. PMID 10551867. 

Dodatna literatura[уреди]

  • Yamada Y, Post SR, Wang K; et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251—5. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. 
  • Reubi JC, Waser B, Schaer JC, Markwalder R (1995). „Somatostatin receptors in human prostate and prostate cancer.”. J. Clin. Endocrinol. Metab. 80 (9): 2806—14. doi:10.1210/jc.80.9.2806. PMID 7673428. 
  • Kagimoto S, Yamada Y, Kubota A; et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188—95. doi:10.1006/bbrc.1994.2054. PMID 7914078. 
  • Fujita T, Yamaji Y, Sato M; et al. (1994). „Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.”. Life Sci. 55 (23): 1797—806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260. 
  • Patel YC, Greenwood M, Kent G; et al. (1993). „Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.”. Biochem. Biophys. Res. Commun. 192 (1): 288—94. doi:10.1006/bbrc.1993.1412. PMID 8386508. 
  • Fukusumi S, Kitada C, Takekawa S; et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157—63. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
  • Jaïs P, Terris B, Ruszniewski P; et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639—44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
  • Lopez F, Estève JP, Buscail L; et al. (1997). „The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.”. J. Biol. Chem. 272 (39): 24448—54. doi:10.1074/jbc.272.39.24448. PMID 9305905. 
  • Tsutsumi A, Takano H, Ichikawa K; et al. (1997). „Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.”. Cell. Immunol. 181 (1): 44—9. doi:10.1006/cimm.1997.1193. PMID 9344495. 
  • Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82—90. doi:10.1210/me.13.1.82. PMID 9892014. 
  • Kumar U, Sasi R, Suresh S; et al. (1999). „Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.”. Diabetes 48 (1): 77—85. doi:10.2337/diabetes.48.1.77. PMID 9892225. 
  • Zitzer H, Richter D, Kreienkamp HJ (1999). „Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.”. J. Biol. Chem. 274 (26): 18153—6. doi:10.1074/jbc.274.26.18153. PMID 10373412. 
  • Zitzer H, Hönck HH, Bächner D; et al. (2000). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.”. J. Biol. Chem. 274 (46): 32997—3001. doi:10.1074/jbc.274.46.32997. PMID 10551867. 
  • Petersenn S, Rasch AC, Presch S; et al. (2000). „Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.”. Mol. Cell. Endocrinol. 157 (1-2): 75—85. doi:10.1016/S0303-7207(99)00161-6. PMID 10619399. 
  • Kreienkamp HJ, Zitzer H, Richter D (2001). „Identification of proteins interacting with the rat somatostatin receptor subtype 2.”. J. Physiol. Paris 94 (3-4): 193—8. doi:10.1016/S0928-4257(00)00204-7. PMID 11087996. 
  • Ho MK, Yung LY, Chan JS; et al. (2001). „Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.”. Br. J. Pharmacol. 132 (7): 1431—40. doi:10.1038/sj.bjp.0703933. PMC 1572686. PMID 11264236. 
  • Zatelli MC, Tagliati F, Taylor JE; et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161—9. doi:10.1210/jc.86.5.2161. PMID 11344221. 
  • Talme T, Ivanoff J, Hägglund M; et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71—9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428. 
  • Klisovic DD, O'Dorisio MS, Katz SE; et al. (2001). „Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.”. Invest. Ophthalmol. Vis. Sci. 42 (10): 2193—201. PMID 11527930. 

Spoljašnje veze[уреди]