Receptor paratiroidnog hormona

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Receptor paratiroidnog hormona 1
Identifikatori
Simbol PTH1R
Alt. simboli PTHR
Entrez 5745
HUGO 9608
OMIM 168468
RefSeq NM_000316
UniProt Q03431
Drugi podaci
Lokus Hromozom 3 p22-p21.1
Receptor paratiroidnog hormona 2
Identifikatori
Simbol PTH2R
Entrez 5746
HUGO 9609
OMIM 601469
RefSeq NM_005048
UniProt P49190
Drugi podaci
Lokus Hromozom 2 q33

Postoje dva receptora paratiroidnog hormona kod sisara: PTH1R i PTH2R. Za ove receptore se vezuje paratiroidni hormon. Oni su članovi GPCR familije transmembranskih proteina.[1]

Reference[уреди]

  1. Jüppner H (1994). „Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors“. Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. DOI:10.1097/00041552-199407000-00002. PMID 8076140. 
  2. Mannstadt M, Jüppner H, Gardella TJ (1999). „Receptors for PTH and PTHrP: their biological importance and functional properties“. Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229. 
  3. Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). „G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells“. Mol. Endocrinol. 10 (5): 566–74. DOI:10.1210/me.10.5.566. PMID 8732687. 
  4. Usdin TB, Bonner TI, Hoare SR (2002). „The parathyroid hormone 2 (PTH2) receptor“. Recept. Channels 8 (3–4): 211–8. DOI:10.1080/10606820213682. PMID 12529938. 

Spoljašnje veze[уреди]