Apelinski receptor

Apelinski receptor
Apelinski receptor
Identifikatori
Simboli	APLNR; FLJ90771; MGC45246; AGTRL1; HG11; APJR; APJ; FLJ96609
Vanjski ID	OMIM: 600052 MGI: 1346086 HomoloGene: 3784 IUPHAR: APJ GeneCards: APLNR Gene
Ontologija gena
Molekularna funkcija	• aktivnost purinskog nukleotidnog receptora, G-protein spregnutog; • aktivnost bradikininskog receptora; • aktivnost angiotenzinskog tip II receptora; • receptorska aktivnost; • aktivnost C-C hemokinskog receptora; • aktivnost receptora trombocit aktivirajućeg faktora; • aktivnost N-formil peptidnog receptora; • aktivnost G-protein spregnutog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom; • ćelijska membrana;
Biološki proces	• signalni put G-protein spregnutog receptora; • prenos signala; • hemotaksa;
Ortolozi
Vrsta	Čovek
Entrez	187
Ensembl	ENSG00000134817
UniProt	P35414
RefSeq (mRNA)	NM_005161
RefSeq (protein)	NP_005152
Lokacija (UCSC)	Chr 11:; 56.76 - 56.76 Mb
PubMed pretraga	[1]

Apelinski receptor (takođe poznat APJ receptor) je G protein-spregnuti receptor^[1] koji vezuje apelin.^[2]^[3]^[4]

Literatura

^ O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T (1993). . „A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11”. Gene. 136 (1-2): 355—60. PMID 8294032. doi:10.1016/0378-1119(93)90495-O.
^ Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M (1998). . „Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor”. Biochem. Biophys. Res. Commun.. 251 (2): 471—6. PMID 9792798. doi:10.1006/bbrc.1998.9489.
^ Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR, O'Dowd BF (2000). . „Characterization of apelin, the ligand for the APJ receptor”. J. Neurochem.. 74 (1): 34—41. PMID 10617103. doi:10.1046/j.1471-4159.2000.0740034.x.
^ Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M, Ruskoaho H (2002). . „Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility”. Circ. Res.. 91 (5): 434—40. PMID 12215493. doi:10.1161/01.RES.0000033522.37861.69.

Dodatna literatura

Hinohara K; Nakajima T; Sasaoka T; et al. (2009). . „Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations.”. J. Hum. Genet.. 54 (9): HASH(0x28fffa0). PMID 19680269. doi:10.1038/jhg.2009.78.
Hata J; Matsuda K; Ninomiya T; et al. (2007). . „Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction.”. Hum. Mol. Genet.. 16 (6): 630—9. PMID 17309882. doi:10.1093/hmg/ddm005.
Kälin RE; Kretz MP; Meyer AM; et al. (2007). . „Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.”. Dev. Biol.. 305 (2): 599—614. PMID 17412318. doi:10.1016/j.ydbio.2007.03.004.
Zhou N; Zhang X; Fan X; et al. (2003). . „The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.”. Virology. 317 (1): 84—94. PMID 14675627. doi:10.1016/j.virol.2003.08.026.
Otsuki T; Ota T; Nishikawa T; et al. (2005). . „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res.. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117.
O'Carroll AM, Don AL, Lolait SJ (2003). . „APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids.”. J. Neuroendocrinol.. 15 (11): 1095—101. PMID 14622440. doi:10.1046/j.1365-2826.2003.01102.x.
Sarzani R; Forleo C; Pietrucci F; et al. (2007). . „The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy.”. J. Card. Fail.. 13 (7): 521—9. PMID 17826642. doi:10.1016/j.cardfail.2007.04.002.
Langelaan DN, Bebbington EM, Reddy T, Rainey JK (2009). . „Structural insight into G-protein coupled receptor binding by apelin.”. Biochemistry. 48 (3): 537—48. PMID 19123778. doi:10.1021/bi801864b.
Zhou N; Fan X; Mukhtar M; et al. (2003). . „Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ.”. Virology. 307 (1): 22—36. PMID 12667811. doi:10.1016/S0042-6822(02)00021-1.
Li WW; Niu WQ; Zhang Y; et al. (2009). . „Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese.”. J. Hypertens.. 27 (6): 1194—201. PMID 19307984. doi:10.1097/HJH.0b013e32832a3eb1.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). . „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Lee DK; LanÃ§a AJ; Cheng R; et al. (2004). . „Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors.”. J. Biol. Chem.. 279 (9): 7901—8. PMID 14645236. doi:10.1074/jbc.M306377200.
Choe H; Martin KA; Farzan M; et al. (1998). . „Structural interactions between chemokine receptors, gp120 Env and CD4.”. Semin. Immunol.. 10 (3): 249—57. PMID 9653051. doi:10.1006/smim.1998.0127.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). . „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet.. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Kleinz MJ, Skepper JN, Davenport AP (2005). . „Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.”. Regul. Pept.. 126 (3): 233—40. PMID 15664671. doi:10.1016/j.regpep.2004.10.019.
Luttrell LM (2008). . „Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.”. Mol. Biotechnol.. 39 (3): 239—64. PMID 18240029. doi:10.1007/s12033-008-9031-1.
Cobellis L; De Falco M; Mastrogiacomo A; et al. (2007). . „Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas.”. Histol. Histopathol.. 22 (1): 1—8. PMID 17128405.
Kubo M (2008). . „[Genetic risk factors of ischemic stroke identified by a genome-wide association study]”. Brain and nerve = Shinkei kenkyÅ« no shinpo. 60 (11): 1339—46. PMID 19069168.
Bai B; Tang J; Liu H; et al. (2008). . „Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway.”. Acta Biochim. Biophys. Sin. (Shanghai). 40 (4): 311—8. PMID 18401529. doi:10.1111/j.1745-7270.2008.00403.x.
Ishida J; Hashimoto T; Hashimoto Y; et al. (2004). . „Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo.”. J. Biol. Chem.. 279 (25): 26274—9. PMID 15087458. doi:10.1074/jbc.M404149200.

Spoljašnje veze

„Apelin Receptor: APJ”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 16. 08. 2021. г..
Apelin+receptor,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid8294032-1] O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T (1993). . „A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11”. Gene. 136 (1-2): 355—60. PMID 8294032. doi:10.1016/0378-1119(93)90495-O.

[pmid9792798-2] Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M (1998). . „Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor”. Biochem. Biophys. Res. Commun.. 251 (2): 471—6. PMID 9792798. doi:10.1006/bbrc.1998.9489.

[pmid10617103-3] Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR, O'Dowd BF (2000). . „Characterization of apelin, the ligand for the APJ receptor”. J. Neurochem.. 74 (1): 34—41. PMID 10617103. doi:10.1046/j.1471-4159.2000.0740034.x.

[pmid12215493-4] Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M, Ruskoaho H (2002). . „Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility”. Circ. Res.. 91 (5): 434—40. PMID 12215493. doi:10.1161/01.RES.0000033522.37861.69.

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