Formil peptidni receptor 2

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Formil peptidni receptor 2
Vanjski ID OMIM136538 MGI1278319 HomoloGene74395 IUPHAR: FPR2/ALX GeneCards: FPR2 Gene
Pregled RNK izražavanja
PBB GE FPRL1 210772 at tn.png
PBB GE FPRL1 210773 s at tn.png
Vrsta Čovek Miš
Entrez 2358 14289
Ensembl ENSG00000171049 ENSMUSG00000052270
UniProt P25090 O88536
RefSeq (mRNA) NM_001005738 NM_008039
RefSeq (protein) NP_001005738 NP_032065
Lokacija (UCSC) Chr 19:
56.96 - 56.97 Mb
Chr 17:
18.02 - 18.03 Mb
PubMed pretraga [1] [2]

N-formil peptidni receptor 2 je protein koji je kod ljudi kodiran FPR2 genom.[1][2]

Vidi još[уреди]


  1. Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (1997). „Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor”. J Biol Chem. 272 (11): 6972—8. PMID 9054386. 
  2. „Entrez Gene: FPRL1 Formyl peptide receptor-like 1”. 

Spoljašnje veze[уреди]

Dodatna literatura[уреди]

  • Murphy PM, Ozçelik T, Kenney RT; et al. (1992). „A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.”. J. Biol. Chem. 267 (11): 7637—43. PMID 1373134. 
  • Ye RD, Cavanagh SL, Quehenberger O; et al. (1992). „Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.”. Biochem. Biophys. Res. Commun. 184 (2): 582—9. doi:10.1016/0006-291X(92)90629-Y. PMID 1374236. 
  • Perez HD, Holmes R, Kelly E; et al. (1992). „Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.”. Gene. 118 (2): 303—4. doi:10.1016/0378-1119(92)90208-7. PMID 1511907. 
  • Bao L, Gerard NP, Eddy RL; et al. (1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.”. Genomics. 13 (2): 437—40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Nomura H, Nielsen BW, Matsushima K (1994). „Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.”. Int. Immunol. 5 (10): 1239—49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
  • Durstin M, Gao JL, Tiffany HL; et al. (1994). „Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.”. Biochem. Biophys. Res. Commun. 201 (1): 174—9. doi:10.1006/bbrc.1994.1685. PMID 8198572. 
  • Takano T, Fiore S, Maddox JF; et al. (1997). „Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.”. J. Exp. Med. 185 (9): 1693—704. doi:10.1084/jem.185.9.1693. PMID 9151906. 
  • Gronert K, Gewirtz A, Madara JL, Serhan CN (1998). „Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.”. J. Exp. Med. 187 (8): 1285—94. doi:10.1084/jem.187.8.1285. PMID 9547339. 
  • Deng X, Ueda H, Su SB; et al. (1999). „A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.”. Blood. 94 (4): 1165—73. PMID 10438703. 
  • Chiang N, Fierro IM, Gronert K, Serhan CN (2000). „Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation.”. J. Exp. Med. 191 (7): 1197—208. doi:10.1084/jem.191.7.1197. PMID 10748237. 
  • Shen W, Proost P, Li B; et al. (2000). „Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.”. Biochem. Biophys. Res. Commun. 272 (1): 276—83. doi:10.1006/bbrc.2000.2770. PMID 10872839. 
  • Le Y, Jiang S, Hu J; et al. (2000). „N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.”. Clin. Immunol. 96 (3): 236—42. doi:10.1006/clim.2000.4896. PMID 10964542. 
  • De Yang , Chen Q, Schmidt AP; et al. (2000). „LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.”. J. Exp. Med. 192 (7): 1069—74. doi:10.1084/jem.192.7.1069. PMID 11015447. 
  • Kang Y, Taddeo B, Varai G; et al. (2000). „Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.”. Biochemistry. 39 (44): 13551—7. doi:10.1021/bi001196i. PMID 11063592. 
  • Svensson L, Dahlgren C, Wennerås C (2002). „The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1.”. J. Leukoc. Biol. 72 (4): 810—8. PMID 12377951. 
  • He R, Sang H, Ye RD (2003). „Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R.”. Blood. 101 (4): 1572—81. doi:10.1182/blood-2002-05-1431. PMID 12393391. 
  • Christophe T, Karlsson A, Rabiet MJ; et al. (2002). „Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.”. Scand. J. Immunol. 56 (5): 470—6. doi:10.1046/j.1365-3083.2002.01149.x. PMID 12410796. 
  • Kucharzik T, Gewirtz AT, Merlin D; et al. (2003). „Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.”. Am. J. Physiol., Cell Physiol. 284 (4): C888—96. doi:10.1152/ajpcell.00507.2001. PMID 12456400. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMID 12477932.