RXFP2

Из Википедије, слободне енциклопедије
Relaksinu/insulinu-slična familija, peptidni receptor 2
Identifikatori
Simboli RXFP2; GPR106; GREAT; INSL3R; LGR8; LGR8.1
Vanjski ID OMIM606655 MGI2153463 HomoloGene15402 IUPHAR: RXFP2 GeneCards: RXFP2 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 122042 140498
Ensembl ENSG00000133105 ENSMUSG00000053368
UniProt Q8WXD0 Q0VB90
RefSeq (mRNA) NM_130806 NM_080468
RefSeq (protein) NP_570718 NP_536716
Lokacija (UCSC) Chr 13:
31.21 - 31.28 Mb
Chr 5:
150.29 - 150.35 Mb
PubMed pretraga [1] [2]

RXFP2, relaksinu/insulinu-slična familija, peptidni receptor 2, je humani G-protein spregnuti receptor.[1]

Vidi još[уреди]

Literatura[уреди]

Dodatna literatura[уреди]

  • Bathgate RA, Ivell R, Sanborn BM; et al. (2005). „Receptors for relaxin family peptides.”. Ann. N. Y. Acad. Sci. 1041: 61—76. doi:10.1196/annals.1282.010. PMID 15956688. 
  • Bathgate RA, Ivell R, Sanborn BM; et al. (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.”. Pharmacol. Rev. 58 (1): 7—31. doi:10.1124/pr.58.1.9. PMID 16507880. 
  • Hsu SY, Nakabayashi K, Nishi S; et al. (2002). „Activation of orphan receptors by the hormone relaxin.”. Science. 295 (5555): 671—4. doi:10.1126/science.1065654. PMID 11809971. 
  • Kumagai J, Hsu SY, Matsumi H; et al. (2002). „INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.”. J. Biol. Chem. 277 (35): 31283—6. doi:10.1074/jbc.C200398200. PMID 12114498. 
  • Gorlov IP, Kamat A, Bogatcheva NV; et al. (2003). „Mutations of the GREAT gene cause cryptorchidism.”. Hum. Mol. Genet. 11 (19): 2309—18. doi:10.1093/hmg/11.19.2309. PMID 12217959. 
  • Sudo S, Kumagai J, Nishi S; et al. (2003). „H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2.”. J. Biol. Chem. 278 (10): 7855—62. doi:10.1074/jbc.M212457200. PMID 12506116. 
  • Ferlin A, Simonato M, Bartoloni L; et al. (2003). „The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.”. J. Clin. Endocrinol. Metab. 88 (9): 4273—9. doi:10.1210/jc.2003-030359. PMID 12970298. 
  • Roh J, Virtanen H, Kumagai J; et al. (2004). „Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism.”. Reprod. Biomed. Online. 7 (4): 400—6. doi:10.1016/S1472-6483(10)61883-4. PMID 14656401. 
  • Vinci G, Anjot MN, Trivin C; et al. (2005). „An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia.”. J. Clin. Endocrinol. Metab. 89 (12): 6282—5. doi:10.1210/jc.2004-0891. PMID 15579790. 
  • Büllesbach EE, Schwabe C (2005). „LGR8 signal activation by the relaxin-like factor.”. J. Biol. Chem. 280 (15): 14586—90. doi:10.1074/jbc.M414443200. PMID 15708846. 
  • Muda M, He C, Martini PG; et al. (2005). „Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.”. Mol. Hum. Reprod. 11 (8): 591—600. doi:10.1093/molehr/gah205. PMID 16051677. 
  • Rosengren KJ, Zhang S, Lin F; et al. (2006). „Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.”. J. Biol. Chem. 281 (38): 28287—95. doi:10.1074/jbc.M603829200. PMID 16867980. 
  • Bogatcheva NV, Ferlin A, Feng S; et al. (2007). „T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.”. Am. J. Physiol. Endocrinol. Metab. 292 (1): E138—44. doi:10.1152/ajpendo.00228.2006. PMID 16926383. 
  • Scott DJ, Layfield S, Yan Y; et al. (2007). „Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.”. J. Biol. Chem. 281 (46): 34942—54. doi:10.1074/jbc.M602728200. PMID 16963451. 
  • El Houate B, Rouba H, Sibai H; et al. (2007). „Novel mutations involving the INSL3 gene associated with cryptorchidism.”. J. Urol. 177 (5): 1947—51. doi:10.1016/j.juro.2007.01.002. PMID 17437853. 
  • Scott DJ, Wilkinson TN, Zhang S; et al. (2007). „Defining the LGR8 residues involved in binding insulin-like peptide 3.”. Mol. Endocrinol. 21 (7): 1699—712. doi:10.1210/me.2007-0097. PMID 17473281. 

Spoljašnje veze[уреди]