GPR34
| G protein-spregnuti receptor 34 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR34; | ||||||||||
| Vanjski ID | OMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2857 | 23890 | |||||||||
| Ensembl | ENSG00000171659 | ENSMUSG00000040229 | |||||||||
| UniProt | Q9UPC5 | Q3USC5 | |||||||||
| RefSeq (mRNA) | NM_001033513 | NM_011823 | |||||||||
| RefSeq (protein) | NP_001028685 | NP_035953 | |||||||||
| Lokacija (UCSC) |
Chr X: 41.43 - 41.44 Mb |
Chr X: 12.79 - 12.8 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR34, G protein-spregnuti receptor 34, je protein koji je kod čoveka kodiran GPR34 genom.[1][2][3]
G protein-spregnuti receptori, kao što je GPR34, su integralni membranski proteini koji sadrže 7 transmembranskih domaina (TM). Ti proteini prenose signale u unutrašnjost ćelije putem aktivacije heterotrimernih G proteina koji zatim aktiviraju razne efektorske proteine, što ultimatno dovodi do fiziološkog responsa.[3]
Literatura[уреди | уреди извор]
- ^ Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (1999). „A novel subgroup of class I G-protein-coupled receptors”. Biochim Biophys Acta. 1446 (1-2): 57—70. PMID 10395919.
- ^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (1999). „Discovery of three novel orphan G-protein-coupled receptors”. Genomics. 56 (1): 12—21. PMID 10036181. doi:10.1006/geno.1998.5655.
- ^ а б „Entrez Gene: GPR34 G protein-coupled receptor 34”.
Dodatna literatura[уреди | уреди извор]
- Hillier LD; Lennon G; Becker M; et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807—28. PMID 8889549. doi:10.1101/gr.6.9.807.
- Jacobi FK; Broghammer M; Pesch K; et al. (2000). „Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.”. Hum. Genet. 107 (1): 89—91. PMID 10982042. doi:10.1007/s004390050017.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Otsuki T; Ota T; Nishikawa T; et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117.
- Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). „Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.”. Genomics. 87 (2): 254—64. PMID 16338117. doi:10.1016/j.ygeno.2005.10.001.
- Oh JH; Yang JO; Hahn Y; et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome. 16 (12): 942—54. PMID 16341674. doi:10.1007/s00335-005-0075-2.
